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Gene

SREBF1

sterol regulatory element binding transcription factor 1

Summary

Cytogenetic location
17p11.2
Coordinates
Chromosome 17: 17,811,334–17,836,986 (GRCh38)
Exons
19 exons across 25.7 kb
Protein
1,147 amino acids
Also known as
SREBP1, bHLHd1, SREBP-1c, SREBP1a
MANE Select transcript
ENST00000261646.11NM_004176.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SREBF1 yet. The test sequences your whole genome, so your data includes it all the same.

How SREBF1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where SREBF1 sits. SREBF1 and 17 genes near it on chromosome 17, from 17,324,160 to 18,324,159.Chromosome 1717p11.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.317.4 Mb17.6 Mb17.8 Mb18 Mb18.2 MbNT5M: 17,303,316–17,347,663, forward strandNT5MMED9: 17,476,981–17,494,484, forward strandMED9RASD1: 17,494,193–17,496,402, reverse strandRASD1PEMT: 17,505,559–17,592,105, reverse strandPEMTRAI1: 17,681,323–17,811,453, forward strandRAI1SREBF1: 17,811,334–17,836,986, reverse strandSREBF1TOM1L2: 17,843,507–17,972,470, reverse strandTOM1L2DRC3: 17,972,813–18,016,889, forward strandDRC3ATPAF2: 17,977,409–18,040,833, reverse strandATPAF2GID4: 18,039,371–18,068,405, forward strandGID4DRG2: 18,087,876–18,107,979, forward strandDRG2MYO15A: 18,108,756–18,179,802, forward strandMYO15AALKBH5: 18,183,034–18,209,954, forward strandALKBH5LLGL1: 18,225,542–18,244,876, forward strandLLGL1FLII: 18,244,782–18,260,420, reverse strandFLIIMIEF2: 18,259,527–18,266,552, forward strandMIEF2TOP3A: 18,271,428–18,315,025, reverse strandTOP3ASMCR8: 18,315,293–18,328,056, forward strandSMCR8Diagram of SREBF1: 19 exons on the reverse strand of chromosome 17Exon 8: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 19: 17,811,334–17,812,851, 1,518 basesExon 18: 17,813,368–17,813,479, 112 basesExon 17: 17,813,569–17,813,769, 201 basesExon 16: 17,814,245–17,814,410, 166 basesExon 15: 17,814,615–17,814,747, 133 basesExon 14: 17,814,835–17,814,944, 110 basesExon 13: 17,815,221–17,815,329, 109 basesExon 12: 17,815,860–17,816,028, 169 basesExon 11: 17,816,207–17,816,373, 167 basesExon 10: 17,816,457–17,816,718, 262 basesExon 9: 17,816,958–17,817,136, 179 basesExon 8: 17,817,256–17,817,457, 202 basesExon 7: 17,817,696–17,817,916, 221 basesExon 6: 17,818,260–17,818,374, 115 basesExon 5: 17,819,013–17,819,234, 222 basesExon 4: 17,819,320–17,819,454, 135 basesExon 3: 17,819,538–17,819,725, 188 basesExon 2: 17,820,090–17,820,521, 432 basesExon 1: 17,836,727–17,836,986, 260 bases191510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.9 kb of the gene's 25.7 kb; 3,444 of those bases code for the protein.

How a genome test reads SREBF1

3

positions in SREBF1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 25.7 kb of SREBF1, introns included, not only the 4.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SREBF1 gene: sterol regulatory element binding transcription factor 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/srebf1

Vancouver

Dante Labs. SREBF1 gene: sterol regulatory element binding transcription factor 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/srebf1

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