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Gene

TYMS

thymidylate synthetase

Summary

Cytogenetic location
18p11.32
Coordinates
Chromosome 18: 657,653–673,578 (GRCh38)
Exons
7 exons across 15.9 kb
Protein
313 amino acids
Also known as
Tsase, TMS, HsT422
Previous symbols
TS
MANE Select transcript
ENST00000323274.15NM_001071.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TYMS yet. The test sequences your whole genome, so your data includes it all the same.

How TYMS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 18, with a bracket where TYMS sits. TYMS and 8 genes near it on chromosome 18, from 165,616 to 1,165,615.Chromosome 1818p11.32p11.32p11.31p11.23p11.22p11.21p11.1q11.1q11.2q12.1q12.2q12.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q230.2 Mb0.4 Mb0.6 Mb0.8 Mb1 MbUSP14: 158,328–214,629, forward strandUSP14THOC1: 214,249–268,065, reverse strandTHOC1COLEC12: 316,737–500,748, reverse strandCOLEC12CETN1: 580,380–582,114, forward strandCETN1CLUL1: 596,983–650,334, forward strandCLUL1TYMS: 657,653–673,578, forward strandTYMSENOSF1: 667,671–712,722, reverse strandENOSF1YES1: 721,587–813,276, reverse strandYES1ADCYAP1: 904,398–912,172, forward strandADCYAP1Diagram of TYMS: 7 exons on the forward strand of chromosome 18Exon 3: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 7: 1 known disease-causing siteExon 1: 657,653–657,947, 295 basesExon 2: 659,641–659,714, 74 basesExon 3: 662,146–662,320, 175 basesExon 4: 669,072–669,173, 102 basesExon 5: 670,692–670,867, 176 basesExon 6: 671,380–671,451, 72 basesExon 7: 672,860–673,578, 719 bases12345675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 15.9 kb; 942 of those bases code for the protein.

How a genome test reads TYMS

5

positions in TYMS where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 15.9 kb of TYMS, introns included, not only the 1.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TYMS gene: thymidylate synthetase. Retrieved 16 October 2026, from https://dantelabs.com/genes/tyms

Vancouver

Dante Labs. TYMS gene: thymidylate synthetase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tyms

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