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Gene

KRT86

keratin 86

Summary

Cytogenetic location
12q13
Coordinates
Chromosome 12: 52,274,645–52,309,163 (GRCh38)
Exons
11 exons across 34.5 kb
Protein
486 amino acids
Inheritance
Autosomal dominant
Also known as
MNX, Hb6
Previous symbols
KRTHB6
MANE Select transcript
ENST00000423955.7NM_001320198.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How KRT86 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where KRT86 sits. KRT86 and 31 genes near it on chromosome 12, from 51,791,904 to 52,791,903.Chromosome 1212q13p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3351.8 Mb52 Mb52.2 Mb52.4 Mb52.6 MbSCN8A: 51,590,266–51,812,864, forward strandSCN8ATMDD1: 51,813,921–51,814,925, reverse strandTMDD1FIGNL2: 51,817,899–51,848,729, reverse strandFIGNL2ANKRD33: 51,888,009–51,891,727, forward strandANKRD33ACVRL1: 51,906,908–51,923,361, forward strandACVRL1ACVR1B: 51,951,675–51,997,082, forward strandACVR1BTAMALIN: 52,006,941–52,015,893, forward strandTAMALINNR4A1: 52,022,832–52,059,509, forward strandNR4A1ATG101: 52,069,246–52,077,495, forward strandATG101SMIM41: 52,079,704–52,108,255, forward strandSMIM41KRT80: 52,168,996–52,192,311, reverse strandKRT80KRT7: 52,232,520–52,252,186, forward strandKRT7KRT86: 52,274,645–52,309,163, forward strandKRT86KRT81: 52,285,913–52,291,534, reverse strandKRT81KRT83: 52,314,301–52,321,398, reverse strandKRT83KRT85: 52,360,006–52,367,481, reverse strandKRT85KRT84: 52,377,812–52,385,652, reverse strandKRT84KRT82: 52,393,931–52,406,335, reverse strandKRT82KRT75: 52,424,070–52,434,380, reverse strandKRT75KRT6B: 52,446,651–52,452,154, reverse strandKRT6BKRT6C: 52,468,516–52,473,805, reverse strandKRT6CKRT6A: 52,487,176–52,493,265, reverse strandKRT6AKRT5: 52,514,575–52,520,530, reverse strandKRT5KRT71: 52,543,909–52,553,145, reverse strandKRT71KRT74: 52,565,151–52,573,843, reverse strandKRT74KRT72: 52,585,589–52,601,538, reverse strandKRT72KRT73: 52,607,570–52,618,559, reverse strandKRT73KRT2: 52,644,558–52,652,211, reverse strandKRT2KRT1: 52,674,736–52,680,407, reverse strandKRT1KRT77: 52,689,626–52,703,524, reverse strandKRT77KRT76: 52,768,155–52,777,345, reverse strandKRT76KRT3: 52,789,685–52,796,117, reverse strandKRT3Diagram of KRT86: 11 exons on the forward strand of chromosome 12Exon 9: 1 known disease-causing siteExon 1: 52,274,645–52,274,722, 78 basesExon 2: 52,275,821–52,275,946, 126 basesExon 3: 52,301,913–52,302,285, 373 basesExon 4: 52,303,100–52,303,308, 209 basesExon 5: 52,304,111–52,304,171, 61 basesExon 6: 52,304,932–52,305,027, 96 basesExon 7: 52,305,240–52,305,404, 165 basesExon 8: 52,305,663–52,305,788, 126 basesExon 9: 52,306,060–52,306,280, 221 basesExon 10: 52,308,233–52,308,264, 32 basesExon 11: 52,308,404–52,309,163, 760 bases1115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 34.5 kb; 1,461 of those bases code for the protein.

How a genome test reads KRT86

1

position in KRT86 where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (100%) falls in a region short reads find hard.

  • Segmental duplications (1 site)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 34.5 kb of KRT86, introns included, not only the 2.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KRT86 gene: keratin 86. Retrieved 16 October 2026, from https://dantelabs.com/genes/krt86

Vancouver

Dante Labs. KRT86 gene: keratin 86 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/krt86

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