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Gene

TRPV3

transient receptor potential cation channel subfamily V member 3

Summary

Cytogenetic location
17p13.2
Coordinates
Chromosome 17: 3,510,502–3,557,812 (GRCh38)
Exons
18 exons across 47.3 kb
Protein
790 amino acids
Also known as
VRL3
MANE Select transcript
ENST00000576742.6NM_145068.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Palmoplantar Keratodermas and Pachyonychia Congenita

    • Hereditary palmoplantar keratoderma

      Inherited thickening of the palms and soles, including pachyonychia congenita, mal de Meleda, Nagashima-type and Bothnian keratodermas, keratitis-ichthyosis-deafness syndrome, and the CTSC-related Papillon-Lefèvre and Haim-Munk syndromes.

      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Diagnosis guides foot care and pain management; for CTSC-related forms early dental treatment protects the teeth, and GJB2-related forms warrant a hearing check.

How TRPV3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where TRPV3 sits. TRPV3 and 30 genes near it on chromosome 17, from 3,034,157 to 4,034,156.Chromosome 1717p13.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.33.2 Mb3.4 Mb3.6 Mb3.8 Mb4 MbRAP1GAP2: 2,755,629–3,037,741, forward strandRAP1GAP2OR1D5: 3,062,669–3,063,607, reverse strandOR1D5OR1D2: 3,088,484–3,104,422, reverse strandOR1D2OR1G1: 3,126,610–3,127,551, reverse strandOR1G1OR1P1: 3,153,890–3,154,882, reverse strandOR1P1OR1A2: 3,197,519–3,198,448, forward strandOR1A2OR1A1: 3,207,539–3,218,896, forward strandOR1A1OR3A2: 3,276,177–3,386,328, reverse strandOR3A2OR3A1: 3,291,017–3,298,360, reverse strandOR3A1OR1R1: 3,385,930–3,386,874, forward strandOR1R1OR1E1: 3,397,104–3,398,410, reverse strandOR1E1OR3A3: 3,411,370–3,424,070, forward strandOR3A3OR1E2: 3,432,870–3,433,841, reverse strandOR1E2SPATA22: 3,440,011–3,513,852, reverse strandSPATA22ASPA: 3,472,374–3,503,405, forward strandASPATRPV3: 3,510,502–3,557,812, reverse strandTRPV3TRPV1: 3,565,444–3,609,880, reverse strandTRPV1: 3,585,149–3,636,249, reverse strandSHPK: 3,607,433–3,636,637, reverse strandSHPKCTNS: 3,636,446–3,663,103, forward strandCTNSTAX1BP3: 3,659,751–3,668,679, reverse strandTAX1BP3P2RX5-TAX1BP3: 3,663,063–3,696,194, reverse strandEMC6: 3,668,794–3,672,835, forward strandEMC6P2RX5: 3,669,763–3,696,398, reverse strandITGAE: 3,714,628–3,801,225, reverse strandITGAEHASPIN: 3,723,903–3,726,699, forward strandHASPINNCBP3: 3,802,158–3,846,263, reverse strandNCBP3CAMKK1: 3,860,315–3,894,891, reverse strandCAMKK1P2RX1: 3,896,592–3,916,580, reverse strandP2RX1ATP2A3: 3,923,866–3,964,499, reverse strandATP2A3ZZEF1: 4,004,432–4,143,628, reverse strandZZEF1Diagram of TRPV3: 18 exons on the reverse strand of chromosome 17Exon 15: 1 known disease-causing siteExon 13: 2 known disease-causing sitesExon 18: 3,510,502–3,514,011, 3,510 basesExon 17: 3,514,593–3,514,672, 80 basesExon 16: 3,516,457–3,516,569, 113 basesExon 15: 3,518,576–3,518,850, 275 basesExon 14: 3,520,973–3,521,039, 67 basesExon 13: 3,524,198–3,524,363, 166 basesExon 12: 3,526,854–3,526,927, 74 basesExon 11: 3,528,025–3,528,126, 102 basesExon 10: 3,528,837–3,528,995, 159 basesExon 9: 3,530,027–3,530,203, 177 basesExon 8: 3,532,657–3,532,937, 281 basesExon 7: 3,535,573–3,535,713, 141 basesExon 6: 3,542,522–3,542,698, 177 basesExon 5: 3,543,474–3,543,628, 155 basesExon 4: 3,544,579–3,544,665, 87 basesExon 3: 3,545,167–3,545,271, 105 basesExon 2: 3,554,732–3,554,852, 121 basesExon 1: 3,557,676–3,557,812, 137 bases1816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.9 kb of the gene's 47.3 kb; 2,373 of those bases code for the protein.

How a genome test reads TRPV3

3

positions in TRPV3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 47.3 kb of TRPV3, introns included, not only the 5.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TRPV3 gene: transient receptor potential cation channel subfamily V member 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/trpv3

Vancouver

Dante Labs. TRPV3 gene: transient receptor potential cation channel subfamily V member 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/trpv3

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