Skip to content
Use your HSA or FSA funds

Gene

TERC

telomerase RNA component

Summary

Cytogenetic location
3q26.2
Coordinates
Chromosome 3: 169,764,610–169,765,060 (GRCh38)
Exons
1 exon across 0.5 kb
Also known as
TR, hTR, TRC3, SCARNA19, TER
MANE Select transcript
ENST00000602385.3NR_001566.3
Locus type
RNA, long non-coding

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Dyskeratosis Congenita

    • Dyskeratosis congenita (DC) is a rare ectodermal dysplasia that often presents with the classic triad of nail dysplasia, skin pigmentary changes, and oral leukoplakia associated with a high risk of bone marrow failure (BMF) and cancer.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
    • Telomere syndromes

      Disorders of short telomeres caused by variants in telomere-maintenance genes such as TERT, TERC, RTEL1 and PARN, which can cause bone marrow failure, lung fibrosis and liver disease even without classic skin signs.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Monitoring of blood counts, lungs and liver is advised, and the diagnosis informs donor selection and treatment choices for stem cell transplantation.

How TERC is laid out

  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 3, with a bracket where TERC sits. TERC and 11 genes near it on chromosome 3, from 169,264,835 to 170,264,834.Chromosome 33q26.2p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29169.4 Mb169.6 Mb169.8 Mb170 Mb170.2 MbMECOM: 169,083,499–169,663,775, reverse strandMECOMTERC: 169,764,610–169,765,060, reverse strandTERCACTRT3: 169,765,610–169,769,851, reverse strandACTRT3MYNN: 169,773,377–169,790,449, forward strandMYNNLRRC34: 169,793,003–169,813,008, reverse strandLRRC34LRRIQ4: 169,812,870–169,837,773, forward strandLRRIQ4LRRC31: 169,837,917–169,870,000, reverse strandLRRC31SAMD7: 169,911,572–169,939,175, forward strandSAMD7SEC62: 169,966,635–169,998,373, forward strandSEC62GPR160: 170,037,451–170,089,944, forward strandGPR160PHC3: 170,086,732–170,181,768, reverse strandPHC3PRKCI: 170,222,124–170,322,329, forward strandPRKCIDiagram of TERC: one exon on the reverse strand of chromosome 3Exon 1: 16 known disease-causing sitesExon 1: 169,764,610–169,765,060, 451 bases15′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.5 kb of the gene's 0.5 kb.

How a genome test reads TERC

19

positions in TERC where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 0.5 kb of TERC, introns included, not only the 0.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TERC gene: telomerase RNA component. Retrieved 16 October 2026, from https://dantelabs.com/genes/terc

Vancouver

Dante Labs. TERC gene: telomerase RNA component [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/terc

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test