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Gene

RPA1

replication protein A1

Summary

Cytogenetic location
17p13.3
Coordinates
Chromosome 17: 1,830,005–1,900,082 (GRCh38)
Exons
17 exons across 70.1 kb
Protein
616 amino acids
Also known as
REPA1, RPA70, HSSB, RF-A, RP-A
MANE Select transcript
ENST00000254719.10NM_002945.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Dyskeratosis Congenita

    • Telomere syndromes

      Disorders of short telomeres caused by variants in telomere-maintenance genes such as TERT, TERC, RTEL1 and PARN, which can cause bone marrow failure, lung fibrosis and liver disease even without classic skin signs.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Monitoring of blood counts, lungs and liver is advised, and the diagnosis informs donor selection and treatment choices for stem cell transplantation.

  • Familial Pulmonary Fibrosis

    • Telomere-related Pulmonary Fibrosis and/or Bone Marrow Failure

      Variants in telomere-maintenance genes such as TERT, TERC, RTEL1 and PARN can cause progressive pulmonary fibrosis in adulthood, sometimes together with bone marrow failure or liver disease.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing can prompt earlier lung monitoring and treatment, screening for blood and liver involvement, care with immunosuppressive drugs around transplant, and careful selection of related donors.

How RPA1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 17, with a bracket where RPA1 sits. RPA1 and 22 genes near it on chromosome 17, from 1,365,044 to 2,365,043.Chromosome 1717p13.3p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.31.4 Mb1.6 Mb1.8 Mb2 Mb2.2 MbYWHAE: 1,344,275–1,400,326, reverse strandYWHAECRK: 1,420,689–1,463,162, reverse strandCRKMYO1C: 1,464,186–1,492,707, reverse strandMYO1CINPP5K: 1,494,571–1,516,759, reverse strandINPP5KPITPNA: 1,517,718–1,562,861, reverse strandPITPNASLC43A2: 1,569,268–1,630,103, reverse strandSLC43A2SCARF1: 1,633,848–1,646,122, reverse strandSCARF1RILP: 1,646,138–1,650,083, reverse strandRILPPRPF8: 1,650,624–1,684,909, reverse strandPRPF8TLCD2: 1,688,598–1,710,639, reverse strandTLCD2WDR81: 1,716,523–1,738,599, forward strandWDR81SERPINF2: 1,742,069–1,755,271, forward strandSERPINF2SERPINF1: 1,761,958–1,777,627, forward strandSERPINF1SMYD4: 1,779,485–1,830,634, reverse strandSMYD4RPA1: 1,830,005–1,900,082, forward strandRPA1RTN4RL1: 1,934,677–2,025,355, reverse strandRTN4RL1DPH1: 2,030,136–2,043,898, forward strandDPH1OVCA2: 2,042,022–2,043,898, forward strandOVCA2HIC1: 2,054,154–2,063,241, forward strandHIC1SMG6: 2,059,839–2,303,934, reverse strandSMG6SRR: 2,303,383–2,326,656, forward strandSRRTSR1: 2,322,376–2,337,965, reverse strandTSR1SGSM2: 2,337,488–2,381,058, forward strandSGSM2Diagram of RPA1: 17 exons on the forward strand of chromosome 17Exon 1: 1,830,005–1,830,126, 122 basesExon 2: 1,842,803–1,842,853, 51 basesExon 3: 1,843,920–1,843,998, 79 basesExon 4: 1,844,578–1,844,686, 109 basesExon 5: 1,853,101–1,853,189, 89 basesExon 6: 1,872,434–1,872,526, 93 basesExon 7: 1,875,661–1,875,793, 133 basesExon 8: 1,877,212–1,877,314, 103 basesExon 9: 1,878,993–1,879,061, 69 basesExon 10: 1,879,215–1,879,407, 193 basesExon 11: 1,879,560–1,879,699, 140 basesExon 12: 1,880,543–1,880,691, 149 basesExon 13: 1,883,812–1,883,944, 133 basesExon 14: 1,888,675–1,888,851, 177 basesExon 15: 1,891,833–1,891,940, 108 basesExon 16: 1,895,009–1,895,095, 87 basesExon 17: 1,897,071–1,900,082, 3,012 bases151015175′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.8 kb of the gene's 70.1 kb; 1,851 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RPA1 gene: replication protein A1. Retrieved 16 October 2026, from https://dantelabs.com/genes/rpa1

Vancouver

Dante Labs. RPA1 gene: replication protein A1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/rpa1

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