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Gene

KRT85

keratin 85

Summary

Cytogenetic location
12q13.13
Coordinates
Chromosome 12: 52,360,006–52,367,481 (GRCh38)
Exons
9 exons across 7.5 kb
Protein
507 amino acids
Inheritance
Autosomal recessive
Also known as
Hb-5
Previous symbols
KRTHB5
MANE Select transcript
ENST00000257901.7NM_002283.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Ectodermal Dysplasias

    • Ectodermal Dysplasia 4, Hair/Nail TypeAutosomal recessive

      Any pure hair and nail ectodermal dysplasia in which the cause of the disease is a mutation in the KRT85 gene.

      • 3 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How KRT85 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 12, with a bracket where KRT85 sits. KRT85 and 31 genes near it on chromosome 12, from 51,863,744 to 52,863,743.Chromosome 1212q13.13p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3352 Mb52.2 Mb52.4 Mb52.6 Mb52.8 MbANKRD33: 51,888,009–51,891,727, forward strandANKRD33ACVRL1: 51,906,908–51,923,361, forward strandACVRL1ACVR1B: 51,951,675–51,997,082, forward strandACVR1BTAMALIN: 52,006,941–52,015,893, forward strandTAMALINNR4A1: 52,022,832–52,059,509, forward strandNR4A1ATG101: 52,069,246–52,077,495, forward strandATG101SMIM41: 52,079,704–52,108,255, forward strandSMIM41KRT80: 52,168,996–52,192,311, reverse strandKRT80KRT7: 52,232,520–52,252,186, forward strandKRT7KRT86: 52,249,300–52,309,163, forward strandKRT86KRT81: 52,285,913–52,291,534, reverse strandKRT81KRT83: 52,314,301–52,321,398, reverse strandKRT83KRT85: 52,360,006–52,367,481, reverse strandKRT85KRT84: 52,377,812–52,385,652, reverse strandKRT84KRT82: 52,393,931–52,406,335, reverse strandKRT82KRT75: 52,424,070–52,434,380, reverse strandKRT75KRT6B: 52,446,651–52,452,154, reverse strandKRT6BKRT6C: 52,468,516–52,473,805, reverse strandKRT6CKRT6A: 52,487,176–52,493,265, reverse strandKRT6AKRT5: 52,514,575–52,520,530, reverse strandKRT5KRT71: 52,543,909–52,553,145, reverse strandKRT71KRT74: 52,565,151–52,573,843, reverse strandKRT74KRT72: 52,585,589–52,601,538, reverse strandKRT72KRT73: 52,607,570–52,618,559, reverse strandKRT73KRT2: 52,644,558–52,652,211, reverse strandKRT2KRT1: 52,674,736–52,680,407, reverse strandKRT1KRT77: 52,689,626–52,703,524, reverse strandKRT77KRT76: 52,768,155–52,777,345, reverse strandKRT76KRT3: 52,789,685–52,796,117, reverse strandKRT3KRT4: 52,806,549–52,814,116, reverse strandKRT4KRT79: 52,821,408–52,834,312, reverse strandKRT79KRT78: 52,837,804–52,849,092, reverse strandKRT78Diagram of KRT85: 9 exons on the reverse strand of chromosome 12Exon 9: 52,360,006–52,361,046, 1,041 basesExon 8: 52,361,467–52,361,498, 32 basesExon 7: 52,362,251–52,362,471, 221 basesExon 6: 52,362,854–52,362,979, 126 basesExon 5: 52,363,246–52,363,410, 165 basesExon 4: 52,364,068–52,364,163, 96 basesExon 3: 52,364,306–52,364,366, 61 basesExon 2: 52,364,962–52,365,170, 209 basesExon 1: 52,366,986–52,367,481, 496 bases9876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.4 kb of the gene's 7.5 kb; 1,524 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KRT85 gene: keratin 85. Retrieved 17 October 2026, from https://dantelabs.com/genes/krt85

Vancouver

Dante Labs. KRT85 gene: keratin 85 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/krt85

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