Trait
Poor toenail formation
Clinical name: Dystrophic toenail
Toenail changes apart from changes of the color of the toenail (nail dyschromia) that involve partial or complete disruption of the various keratinous layers of the nail plate.
Summary
- Also called
- Dystrophic toenail changes
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
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Get my Genome Test21 genes linked to Poor toenail formation
Changes in these genes cause rare conditions in which Poor toenail formation is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DSTdystonin | Always | In 1 condition |
| KRT5keratin 5 | Always | In 2 conditions |
| KRT74keratin 74 | Always | In 1 condition |
| PERPp53 apoptosis effector related to PMP22 | Always | In 1 condition |
| KIF1Akinesin family member 1A | Very often (80–99%) | In 1 condition |
| RETREG1reticulophagy regulator 1 | Very often (80–99%) | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Very often (80–99%) | In 1 condition |
| WNK1WNK lysine deficient protein kinase 1 | Very often (80–99%) | In 1 condition |
| COL7A1collagen type VII alpha 1 chain | Often (30–79%) | In 4 conditions |
| LMNAlamin A/C | Often (30–79%) | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Often (30–79%) | In 1 condition |
| WNT10AWnt family member 10A | Often (30–79%) | In 2 conditions |
| ZMPSTE24zinc metallopeptidase STE24 | Often (30–79%) | In 1 condition |
| COL17A1collagen type XVII alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| ITGB4integrin subunit beta 4 | Sometimes (5–29%) | In 1 condition |
| KRT14keratin 14 | Sometimes (5–29%) | In 2 conditions |
| RUNX2RUNX family transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| KLHL24kelch like family member 24 | Not recorded | In 1 condition |
| NOTCH1notch receptor 1 | Not recorded | In 1 condition |
| RAB7ARAB7A, member RAS oncogene family | Not recorded | In 1 condition |
| SMARCE1SWI/SNF related BAF chromatin remodeling complex subunit E1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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