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Gene

DCLRE1B

DNA cross-link repair 1B

Summary

Cytogenetic location
1p13.2
Coordinates
Chromosome 1: 113,905,326–113,914,086 (GRCh38)
Exons
4 exons across 8.8 kb
Protein
532 amino acids
Also known as
SNM1B, FLJ12810, FLJ13998, APOLLO
MANE Select transcript
ENST00000650450.2NM_022836.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Dyskeratosis Congenita

    • Dyskeratosis congenita (DC) is a rare ectodermal dysplasia that often presents with the classic triad of nail dysplasia, skin pigmentary changes, and oral leukoplakia associated with a high risk of bone marrow failure (BMF) and cancer.

      • 1 GenCC submitter rates it definitive or strong

How DCLRE1B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 1, with a bracket where DCLRE1B sits. DCLRE1B and 10 genes near it on chromosome 1, from 113,409,706 to 114,409,705.Chromosome 11p13.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44113.6 Mb113.8 Mb114 Mb114.2 Mb114.4 MbMAGI3: 113,390,390–113,687,431, forward strandMAGI3PHTF1: 113,696,052–113,759,908, reverse strandPHTF1RSBN1: 113,761,429–113,812,551, reverse strandRSBN1PTPN22: 113,813,811–113,871,753, reverse strandPTPN22BCL2L15: 113,876,816–113,887,588, reverse strandBCL2L15AP4B1: 113,894,194–113,905,722, reverse strandAP4B1DCLRE1B: 113,905,326–113,914,086, forward strandDCLRE1BHIPK1: 113,929,324–113,977,869, forward strandHIPK1OLFML3: 113,979,024–114,035,572, forward strandOLFML3SYT6: 114,089,291–114,153,880, reverse strandSYT6TRIM33: 114,392,781–114,511,244, reverse strandTRIM33Diagram of DCLRE1B: 4 exons on the forward strand of chromosome 1Exon 1: 113,905,326–113,905,775, 450 basesExon 2: 113,906,996–113,907,161, 166 basesExon 3: 113,908,009–113,908,191, 183 basesExon 4: 113,911,131–113,914,086, 2,956 bases12345′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.8 kb of the gene's 8.8 kb; 1,599 of those bases code for the protein.

Genes linked to the same conditions

Traits linked to DCLRE1B

The Human Phenotype Ontology lists these as features of the rare conditions DCLRE1B can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DCLRE1B gene: DNA cross-link repair 1B. Retrieved 17 October 2026, from https://dantelabs.com/genes/dclre1b

Vancouver

Dante Labs. DCLRE1B gene: DNA cross-link repair 1B [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dclre1b

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