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Gene

LPL

lipoprotein lipase

Summary

Cytogenetic location
8p21.3
Coordinates
Chromosome 8: 19,939,253–19,967,259 (GRCh38)
Exons
10 exons across 28 kb
Protein
475 amino acids
Previous symbols
LIPD
MANE Select transcript
ENST00000650287.1NM_000237.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

How LPL is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 8, with a bracket where LPL sits. LPL and 6 genes near it on chromosome 8, from 19,453,256 to 20,453,255.Chromosome 88p21.3p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.319.6 Mb19.8 Mb20 Mb20.2 Mb20.4 MbCSGALNACT1: 19,404,156–19,758,030, reverse strandCSGALNACT1INTS10: 19,817,147–19,857,714, forward strandINTS10LPL: 19,939,253–19,967,259, forward strandLPLSLC18A1: 20,144,186–20,183,206, reverse strandSLC18A1ATP6V1B2: 20,197,323–20,233,400, forward strandATP6V1B2LZTS1: 20,246,165–20,303,970, reverse strandLZTS1: 20,255,055–20,255,279, reverse strandDiagram of LPL: 10 exons on the forward strand of chromosome 8Exon 1: 2 known disease-causing sitesExon 2: 3 known disease-causing sitesExon 3: 12 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 5: 20 known disease-causing sitesExon 6: 29 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 8: 9 known disease-causing sitesExon 9: 1 known disease-causing siteExon 1: 19,939,253–19,939,528, 276 basesExon 2: 19,948,180–19,948,340, 161 basesExon 3: 19,951,769–19,951,948, 180 basesExon 4: 19,953,310–19,953,421, 112 basesExon 5: 19,954,120–19,954,353, 234 basesExon 6: 19,955,841–19,956,083, 243 basesExon 7: 19,959,260–19,959,380, 121 basesExon 8: 19,960,901–19,961,083, 183 basesExon 9: 19,962,115–19,962,219, 105 basesExon 10: 19,965,310–19,967,259, 1,950 bases123456789105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.6 kb of the gene's 28 kb; 1,428 of those bases code for the protein.

How a genome test reads LPL

91

positions in LPL where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 28 kb of LPL, introns included, not only the 3.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LPL gene: lipoprotein lipase. Retrieved 16 October 2026, from https://dantelabs.com/genes/lpl

Vancouver

Dante Labs. LPL gene: lipoprotein lipase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/lpl

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