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Gene

RHCE

Rh blood group CcEe antigens

Summary

Cytogenetic location
1p36.11
Coordinates
Chromosome 1: 25,362,249–25,420,825 (GRCh38)
Exons
10 exons across 58.6 kb
Protein
417 amino acids
Inheritance
Autosomal dominant
Also known as
CD240CE, SLC42A4
Previous symbols
RH
MANE Select transcript
ENST00000294413.13NM_020485.8
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Red Blood Cell Membrane Disorders

    • Hereditary StomatocytosisAutosomal dominant

      A group of conditions in which red cells leak or gain water and salts, including dehydrated hereditary stomatocytosis (PIEZO1, KCNN4), overhydrated stomatocytosis (RHAG), Southeast Asian ovalocytosis and Rh-deficiency syndrome, causing haemolytic anaemia of varying severity and sometimes iron overload.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Spleen removal should be avoided because it raises the risk of serious blood clots in these conditions.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How RHCE is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 1, with a bracket where RHCE sits. RHCE and 14 genes near it on chromosome 1, from 24,891,537 to 25,891,536.Chromosome 11p36.11p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4425 Mb25.2 Mb25.4 Mb25.6 Mb25.8 MbRUNX3: 24,899,511–24,965,121, reverse strandRUNX3SYF2: 25,220,702–25,232,509, reverse strandSYF2RSRP1: 25,242,248–25,338,244, reverse strandRSRP1RHD: 25,272,393–25,330,445, forward strandRHDTMEM50A: 25,337,915–25,362,362, forward strandTMEM50ARHCE: 25,362,249–25,420,825, reverse strandRHCEMACO1: 25,430,853–25,500,209, forward strandMACO1LDLRAP1: 25,543,550–25,591,296, forward strandLDLRAP1MAN1C1: 25,616,788–25,786,206, forward strandMAN1C1SELENON: 25,800,180–25,818,221, forward strandSELENON: 25,811,470–25,823,744, forward strandMTFR1L: 25,818,640–25,835,879, forward strandMTFR1LAUNIP: 25,831,913–25,859,463, reverse strandAUNIPPAQR7: 25,861,211–25,875,968, reverse strandPAQR7STMN1: 25,884,181–25,908,470, reverse strandSTMN1Diagram of RHCE: 10 exons on the reverse strand of chromosome 1Exon 10: 25,362,249–25,362,553, 305 basesExon 9: 25,370,467–25,370,540, 74 basesExon 8: 25,375,349–25,375,428, 80 basesExon 7: 25,385,711–25,385,844, 134 basesExon 6: 25,388,976–25,389,113, 138 basesExon 5: 25,390,749–25,390,915, 167 basesExon 4: 25,391,994–25,392,141, 148 basesExon 3: 25,402,596–25,402,746, 151 basesExon 2: 25,408,683–25,408,869, 187 basesExon 1: 25,420,639–25,420,825, 187 bases109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 58.6 kb; 1,254 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RHCE gene: Rh blood group CcEe antigens. Retrieved 17 October 2026, from https://dantelabs.com/genes/rhce

Vancouver

Dante Labs. RHCE gene: Rh blood group CcEe antigens [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rhce

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