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Gene

DZIP1L

DAZ interacting zinc finger protein 1 like

Summary

Cytogenetic location
3q22.3
Coordinates
Chromosome 3: 138,061,990–138,115,608 (GRCh38)
Exons
16 exons across 53.6 kb
Protein
767 amino acids
Also known as
FLJ32844, DZIP2
MANE Select transcript
ENST00000327532.7NM_173543.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Polycystic Kidney Disease

    • A usually autosomal dominant and less frequently autosomal recessive genetic disorder characterized by the presence of numerous cysts in the kidneys leading to end-stage renal failure. The autosomal dominant trait is associated with abnormalities on the short arm of chromosome 16. Symptoms in patients with the autosomal dominant trait usually appear at middle age and include abdominal pain, hematuria, and high blood pressure. Patients may develop brain aneurysms and liver cysts. Patients with the autosomal recessive trait present with progressive renal failure early in life and symptoms resulting from hepatic fibrosis. The autosomal recessive trait is associated with abnormalities of chromosome 6. Polycystic kidney disease may also result as a side effect in patients on renal dialysis.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Tolvaptan (Jynarque, FDA 2018) for rapidly progressive ADPKD; blood pressure control (target <110/75); pain management; cyst infection treatment; brain MRA screening for intracranial aneurysms; kidney transplantation for ESRD

How DZIP1L is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where DZIP1L sits. DZIP1L and 9 genes near it on chromosome 3, from 137,588,799 to 138,588,798.Chromosome 33q22.3p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29137.6 Mb137.8 Mb138 Mb138.2 Mb138.4 MbSOX14: 137,764,315–137,766,334, forward strandSOX14CLDN18: 137,998,735–138,033,655, forward strandCLDN18DZIP1L: 138,061,990–138,115,608, reverse strandDZIP1LA4GNT: 138,122,901–138,132,416, reverse strandA4GNTDBR1: 138,160,988–138,174,953, reverse strandDBR1ARMC8: 138,187,248–138,298,389, forward strandARMC8NME9: 138,261,437–138,331,354, reverse strandNME9MRAS: 138,347,648–138,405,535, forward strandMRASESYT3: 138,434,570–138,481,686, forward strandESYT3CEP70: 138,494,339–138,594,538, reverse strandCEP70Diagram of DZIP1L: 16 exons on the reverse strand of chromosome 3Exon 15: 1 known disease-causing siteExon 12: 2 known disease-causing sitesExon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 2: 2 known disease-causing sitesExon 16: 138,061,990–138,062,977, 988 basesExon 15: 138,064,628–138,064,767, 140 basesExon 14: 138,067,531–138,067,700, 170 basesExon 13: 138,068,151–138,068,367, 217 basesExon 12: 138,071,643–138,071,835, 193 basesExon 11: 138,077,499–138,077,632, 134 basesExon 10: 138,080,567–138,080,620, 54 basesExon 9: 138,081,734–138,081,764, 31 basesExon 8: 138,084,113–138,084,253, 141 basesExon 7: 138,086,961–138,087,023, 63 basesExon 6: 138,088,379–138,088,507, 129 basesExon 5: 138,092,383–138,092,544, 162 basesExon 4: 138,094,862–138,094,983, 122 basesExon 3: 138,097,763–138,097,847, 85 basesExon 2: 138,103,471–138,104,052, 582 basesExon 1: 138,115,328–138,115,608, 281 bases16141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.5 kb of the gene's 53.6 kb; 2,304 of those bases code for the protein.

How a genome test reads DZIP1L

8

positions in DZIP1L where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 53.6 kb of DZIP1L, introns included, not only the 3.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DZIP1L gene: DAZ interacting zinc finger protein 1 like. Retrieved 17 October 2026, from https://dantelabs.com/genes/dzip1l

Vancouver

Dante Labs. DZIP1L gene: DAZ interacting zinc finger protein 1 like [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dzip1l

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