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Gene

GCLC

glutamate-cysteine ligase catalytic subunit

Summary

Cytogenetic location
6p12.1
Coordinates
Chromosome 6: 53,497,341–53,545,101 (GRCh38)
Exons
16 exons across 47.8 kb
Protein
637 amino acids
Inheritance
Autosomal recessive
Also known as
GCS
Previous symbols
GLCLC, GLCL
MANE Select transcript
ENST00000650454.1NM_001498.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Pyruvate Kinase Deficiency and Other Red Cell Enzyme Disorders

    • Gamma-Glutamylcysteine Synthetase DeficiencyAutosomal recessive

      A rare recessive condition caused by changes in GCLC that lowers glutathione in red cells, causing haemolytic anaemia and sometimes neurological problems.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing about it helps avoid medicines that can trigger haemolysis.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How GCLC is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 6, with a bracket where GCLC sits. GCLC and 9 genes near it on chromosome 6, from 53,021,221 to 54,021,220.Chromosome 66p12.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2753.2 Mb53.4 Mb53.6 Mb53.8 Mb54 MbCILK1: 53,001,279–53,061,896, reverse strandCILK1: 53,041,266–53,041,385, reverse strandFBXO9: 53,051,991–53,101,045, forward strandFBXO9: 53,065,602–53,065,673, forward strandGCM1: 53,126,961–53,148,841, reverse strandGCM1ELOVL5: 53,260,285–53,349,179, reverse strandELOVL5GCLC: 53,497,341–53,545,101, reverse strandGCLCKLHL31: 53,647,916–53,665,868, reverse strandKLHL31LRRC1: 53,793,768–53,924,734, forward strandLRRC1MLIP: 53,929,982–54,267,788, forward strandMLIPDiagram of GCLC: 16 exons on the reverse strand of chromosome 6Exon 16: 53,497,341–53,498,967, 1,627 basesExon 15: 53,500,045–53,500,165, 121 basesExon 14: 53,500,247–53,500,350, 104 basesExon 13: 53,500,432–53,500,513, 82 basesExon 12: 53,505,392–53,505,496, 105 basesExon 11: 53,505,803–53,505,895, 93 basesExon 10: 53,506,913–53,507,025, 113 basesExon 9: 53,507,480–53,507,618, 139 basesExon 8: 53,508,595–53,508,711, 117 basesExon 7: 53,509,176–53,509,250, 75 basesExon 6: 53,514,204–53,514,337, 134 basesExon 5: 53,514,439–53,514,497, 59 basesExon 4: 53,516,109–53,516,222, 114 basesExon 3: 53,520,778–53,520,960, 183 basesExon 2: 53,522,415–53,522,527, 113 basesExon 1: 53,544,496–53,545,101, 606 bases16141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.8 kb of the gene's 47.8 kb; 1,914 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GCLC gene: glutamate-cysteine ligase catalytic subunit. Retrieved 17 October 2026, from https://dantelabs.com/genes/gclc

Vancouver

Dante Labs. GCLC gene: glutamate-cysteine ligase catalytic subunit [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/gclc

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