Gene
SLC30A10
solute carrier family 30 member 10
- HGNC 25355↗(opens in a new tab)
- Ensembl gene ENSG00000196660↗(opens in a new tab)
- NCBI Gene 55532↗(opens in a new tab)
Summary
- Cytogenetic location
- 1q41
- Coordinates
- Chromosome 1: 219,910,445–219,928,557 (GRCh38)
- Exons
- 4 exons across 18.1 kb
- Protein
- 485 amino acids
- Inheritance
- Autosomal recessive
- Also known as
- DKFZp547M236, ZnT-10, ZRC1, ZNT8, ZNT10
- MANE Select transcript
- ENST00000366926.4NM_018713.3
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
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Hereditary Manganese Transporter Disorders
- Hypermanganesemia with DystoniaAutosomal recessive
Accumulation of manganese in the brain and other organs caused by variants in SLC30A10 or SLC39A14, leading to progressive dystonia and parkinsonism and, with SLC30A10, liver disease and polycythaemia.
- 3 GenCC submitters rate it definitive or strong
What knowing changes
Knowing allows early treatment with chelation therapy and iron supplementation, which can lower manganese levels and may improve or stabilise symptoms.
Inheritance
- Autosomal recessive
- It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.
How SLC30A10 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 6.6 kb of the gene's 18.1 kb; 1,458 of those bases code for the protein.
How a genome test reads SLC30A10
3
positions in SLC30A10 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 18.1 kb of SLC30A10, introns included, not only the 6.6 kb of exons.
Genes linked to the same conditions
Traits linked to SLC30A10
The Human Phenotype Ontology lists these as features of the rare conditions SLC30A10 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Dystonia
- Abnormal basal ganglia MRI signal intensity
- Abnormal gait
- Abnormal globus pallidus morphology
- Abnormal myelination
- Action tremor
- Balance impairment
- Difficulty articulating speech
Show 11 more traits
- Difficulty performing quick and alternating movements
- Peripheral neuropathy
- Slow movements
- Astrocytosis
- Instability or lack of coordination of central trunk muscles
- Nerve damage causing decreased feeling and movement
- Poor fine motor coordination
- Abnormality of extrapyramidal motor function
- High stepping
- Parkinsonism
- Tremor
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). SLC30A10 gene: solute carrier family 30 member 10. Retrieved 17 October 2026, from https://dantelabs.com/genes/slc30a10
Dante Labs. SLC30A10 gene: solute carrier family 30 member 10 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/slc30a10
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