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Gene

OCLN

occludin

Summary

Cytogenetic location
5q13.2
Coordinates
Chromosome 5: 69,492,790–69,558,104 (GRCh38)
Exons
9 exons across 65.3 kb
Protein
522 amino acids
Also known as
PPP1R115
MANE Select transcript
ENST00000396442.7NM_001205254.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads OCLN yet. The test sequences your whole genome, so your data includes it all the same.

How OCLN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 5, with a bracket where OCLN sits. OCLN and 14 genes near it on chromosome 5, from 69,025,447 to 70,025,446.Chromosome 55q13.2p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.369.2 Mb69.4 Mb69.6 Mb69.8 Mb70 MbSLC30A5: 69,093,917–69,156,940, forward strandSLC30A5CCNB1: 69,167,004–69,178,389, forward strandCCNB1CENPH: 69,189,537–69,210,357, forward strandCENPHKGD4: 69,217,712–69,231,410, forward strandKGD4CDK7: 69,234,550–69,277,495, forward strandCDK7CCDC125: 69,279,859–69,332,828, reverse strandCCDC125AK6: 69,333,643–69,370,026, reverse strandAK6TAF9: 69,362,026–69,370,026, reverse strandTAF9RAD17: 69,369,293–69,414,806, forward strandRAD17MARVELD2: 69,415,065–69,444,330, forward strandMARVELD2OCLN: 69,492,790–69,558,104, forward strandOCLNGTF2H2C: 69,558,392–69,595,221, forward strandGTF2H2C: 69,632,080–69,636,399, forward strand: 69,898,769–69,903,085, reverse strandSERF1B: 70,025,241–70,043,113, forward strandSERF1BDiagram of OCLN: 9 exons on the forward strand of chromosome 5Exon 3: 4 known disease-causing sitesExon 5: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 1: 69,492,790–69,492,900, 111 basesExon 2: 69,504,177–69,504,294, 118 basesExon 3: 69,509,141–69,509,819, 679 basesExon 4: 69,513,948–69,514,109, 162 basesExon 5: 69,534,694–69,534,839, 146 basesExon 6: 69,544,904–69,545,119, 216 basesExon 7: 69,547,930–69,548,101, 172 basesExon 8: 69,551,544–69,551,585, 42 basesExon 9: 69,553,570–69,558,104, 4,535 bases1234567895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.2 kb of the gene's 65.3 kb; 1,569 of those bases code for the protein.

How a genome test reads OCLN

11

positions in OCLN where ClinVar classes a change as pathogenic or likely pathogenic

6 of them (55%) fall in regions short reads find hard.

  • Low mappability (6 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (6 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 65.3 kb of OCLN, introns included, not only the 6.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). OCLN gene: occludin. Retrieved 16 October 2026, from https://dantelabs.com/genes/ocln

Vancouver

Dante Labs. OCLN gene: occludin [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ocln

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