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Gene

PRSS1

serine protease 1

Summary

Cytogenetic location
7q34
Coordinates
Chromosome 7: 142,749,472–142,753,072 (GRCh38)
Exons
5 exons across 3.6 kb
Protein
247 amino acids
Previous symbols
TRY1
MANE Select transcript
ENST00000311737.12NM_002769.5
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Pancreatitis

    • Inflammation of the pancreas.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      Actionability

      Pain management; pancreatic enzyme replacement for exocrine insufficiency; diabetes management; annual EUS/MRCP surveillance for pancreatic cancer beginning at age 40; total pancreatectomy with islet autotransplantation (TPIAT) in refractory cases

How PRSS1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 7, with a bracket where PRSS1 sits. PRSS1 and 14 genes near it on chromosome 7, from 142,251,272 to 143,251,271.Chromosome 77q34p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3142.4 Mb142.6 Mb142.8 Mb143 Mb143.2 MbPRSS58: 142,252,141–142,258,062, reverse strandPRSS58TRBV11-2: 142,433,895–142,434,394, forward strandTRBV11-2PRSS1: 142,749,472–142,753,072, forward strandPRSS1PRSS2: 142,760,398–142,774,564, forward strandPRSS2EPHB6: 142,854,809–142,872,810, forward strandEPHB6TRPV6: 142,871,208–142,885,781, reverse strandTRPV6TRPV5: 142,904,277–142,933,746, reverse strandTRPV5SOFU1: 142,939,343–142,949,915, forward strandSOFU1KEL: 142,941,114–142,962,369, reverse strandKELOR9A2: 143,026,200–143,027,132, reverse strandOR9A2OR6V1: 143,052,341–143,053,282, forward strandOR6V1PIP: 143,132,077–143,139,746, forward strandPIPTAS2R39: 143,183,419–143,184,435, forward strandTAS2R39TAS2R40: 143,222,037–143,223,079, forward strandTAS2R40GSTK1: 143,244,093–143,272,483, forward strandGSTK1Diagram of PRSS1: 5 exons on the forward strand of chromosome 7Exon 2: 4 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 1: 142,749,472–142,749,524, 53 basesExon 2: 142,750,555–142,750,714, 160 basesExon 3: 142,751,774–142,752,027, 254 basesExon 4: 142,752,431–142,752,567, 137 basesExon 5: 142,752,868–142,753,072, 205 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.8 kb of the gene's 3.6 kb; 744 of those bases code for the protein.

Sequencing PRSS1

8

positions in PRSS1 where ClinVar classes a change as pathogenic or likely pathogenic

8 of them (100%) fall in regions short reads find hard.

  • Segmental duplications (8 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 3.6 kb of PRSS1, introns included, not only the 0.8 kb of exons.

Genes linked to the same conditions

Traits linked to PRSS1

The Human Phenotype Ontology lists these as features of the rare conditions PRSS1 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). PRSS1 gene: serine protease 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/prss1

Vancouver

Dante Labs. PRSS1 gene: serine protease 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/prss1

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