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Gene

ZFYVE19

zinc finger FYVE-type containing 19

Summary

Cytogenetic location
15q15.1
Coordinates
Chromosome 15: 40,807,089–40,815,084 (GRCh38)
Exons
11 exons across 8 kb
Protein
471 amino acids
Inheritance
Autosomal recessive
Also known as
FLJ14840, ANCHR, MPFYVE
MANE Select transcript
ENST00000355341.8NM_001077268.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Familial Intrahepatic Cholestasis

    • Autosomal recessive

      An instance of intrahepatic cholestasis that is caused by an inherited modification of the individual's genome.

      • 3 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How ZFYVE19 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 15, with a bracket where ZFYVE19 sits. ZFYVE19 and 27 genes near it on chromosome 15, from 40,311,087 to 41,311,086.Chromosome 1515q15.1p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.340.4 Mb40.6 Mb40.8 Mb41 Mb41.2 MbINAFM2: 40,323,692–40,326,715, forward strandINAFM2CCDC9B: 40,331,452–40,340,954, reverse strandCCDC9BPHGR1: 40,351,025–40,357,622, forward strandPHGR1DISP2: 40,358,219–40,378,621, forward strandDISP2KNSTRN: 40,382,721–40,395,659, forward strandKNSTRNIVD: 40,405,485–40,435,956, forward strandIVDBAHD1: 40,436,611–40,468,242, forward strandBAHD1CHST14: 40,470,984–40,473,158, forward strandCHST14CCDC32: 40,519,519–40,565,054, reverse strandCCDC32RPUSD2: 40,569,289–40,575,171, forward strandRPUSD2KNL1: 40,594,002–40,664,342, forward strandKNL1RAD51: 40,694,774–40,732,344, forward strandRAD51RMDN3: 40,720,655–40,755,851, reverse strandRMDN3GCHFR: 40,764,043–40,767,872, forward strandDNAJC17: 40,765,161–40,807,498, reverse strandDNAJC17C15orf62: 40,769,980–40,772,449, forward strandC15orf62ZFYVE19: 40,807,089–40,815,084, forward strandZFYVE19PPP1R14D: 40,814,731–40,829,395, reverse strandPPP1R14DSPINT1: 40,843,513–40,860,274, forward strandSPINT1RHOV: 40,872,214–40,874,245, reverse strandRHOVVPS18: 40,894,412–40,903,975, forward strandVPS18DLL4: 40,929,333–40,939,081, forward strandDLL4CHAC1: 40,952,962–40,957,478, forward strandCHAC1INO80: 40,978,880–41,116,568, reverse strandINO80EXD1: 41,182,725–41,230,757, reverse strandEXD1CHP1: 41,230,824–41,281,888, forward strandCHP1: 41,284,007–41,380,996, forward strandOIP5: 41,306,412–41,332,680, reverse strandOIP5Diagram of ZFYVE19: 11 exons on the forward strand of chromosome 15Exon 1: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 1: 40,807,089–40,807,868, 780 basesExon 2: 40,809,119–40,809,240, 122 basesExon 3: 40,809,408–40,809,458, 51 basesExon 4: 40,809,852–40,809,970, 119 basesExon 5: 40,810,071–40,810,216, 146 basesExon 6: 40,810,649–40,810,757, 109 basesExon 7: 40,812,699–40,812,902, 204 basesExon 8: 40,813,338–40,813,417, 80 basesExon 9: 40,813,713–40,813,811, 99 basesExon 10: 40,813,943–40,814,070, 128 basesExon 11: 40,814,148–40,815,084, 937 bases12345678910115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.8 kb of the gene's 8 kb; 1,416 of those bases code for the protein.

How a genome test reads ZFYVE19

3

positions in ZFYVE19 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 8 kb of ZFYVE19, introns included, not only the 2.8 kb of exons.

Genes linked to the same conditions

Traits linked to ZFYVE19

The Human Phenotype Ontology lists these as features of the rare conditions ZFYVE19 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ZFYVE19 gene: zinc finger FYVE-type containing 19. Retrieved 17 October 2026, from https://dantelabs.com/genes/zfyve19

Vancouver

Dante Labs. ZFYVE19 gene: zinc finger FYVE-type containing 19 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/zfyve19

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