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Gene

ABCC2

ATP binding cassette subfamily C member 2

Summary

Cytogenetic location
10q24.2
Coordinates
Chromosome 10: 99,782,640–99,852,594 (GRCh38)
Exons
32 exons across 70 kb
Protein
1,545 amino acids
Inheritance
Autosomal recessive
Also known as
DJS, MRP2, cMRP
Previous symbols
CMOAT
MANE Select transcript
ENST00000647814.1NM_000392.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Gilbert Syndrome

    • Dubin-Johnson SyndromeAutosomal recessive

      Caused by variants in ABCC2, which reduce the release of bilirubin into bile and cause mild lifelong jaundice that is usually harmless.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing explains raised bilirubin results and can avoid unnecessary investigations; jaundice may worsen with pregnancy or oral contraceptives.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How ABCC2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where ABCC2 sits. ABCC2 and 15 genes near it on chromosome 10, from 99,317,617 to 100,317,616.Chromosome 1010q24.2p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.399.4 Mb99.6 Mb99.8 Mb100 Mb100.2 MbCNNM1: 99,329,030–99,394,330, forward strandCNNM1GOT1: 99,396,869–99,431,465, reverse strandGOT1NKX2-3: 99,532,928–99,536,524, forward strandNKX2-3SLC25A28: 99,610,509–99,622,793, reverse strandSLC25A28: 99,651,595–99,732,112, reverse strandENTPD7: 99,659,415–99,712,489, forward strandENTPD7COX15: 99,694,554–99,732,858, reverse strandCOX15CUTC: 99,702,558–99,758,005, forward strandCUTCABCC2: 99,782,640–99,852,594, forward strandABCC2DNMBP: 99,875,576–100,010,049, reverse strandDNMBPCPN1: 100,041,105–100,081,907, reverse strandCPN1ERLIN1: 100,150,094–100,186,062, reverse strandERLIN1CHUK: 100,188,299–100,229,611, reverse strandCHUKCWF19L1: 100,230,024–100,267,685, reverse strandCWF19L1BLOC1S2: 100,272,797–100,286,708, reverse strandBLOC1S2PKD2L1: 100,288,149–100,330,264, reverse strandPKD2L1Diagram of ABCC2: 32 exons on the forward strand of chromosome 10Exon 2: 2 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 8: 4 known disease-causing sitesExon 9: 1 known disease-causing siteExon 10: 2 known disease-causing sitesExon 12: 2 known disease-causing sitesExon 14: 1 known disease-causing siteExon 16: 5 known disease-causing sitesExon 17: 1 known disease-causing siteExon 18: 3 known disease-causing sitesExon 19: 1 known disease-causing siteExon 23: 2 known disease-causing sitesExon 24: 3 known disease-causing sitesExon 25: 4 known disease-causing sitesExon 26: 1 known disease-causing siteExon 27: 3 known disease-causing sitesExon 28: 3 known disease-causing sitesExon 29: 3 known disease-causing sitesExon 30: 4 known disease-causing sitesExon 31: 3 known disease-causing sitesExon 32: 1 known disease-causing siteExon 1: 99,782,640–99,782,877, 238 basesExon 2: 99,784,608–99,784,781, 174 basesExon 3: 99,792,234–99,792,359, 126 basesExon 4: 99,793,551–99,793,685, 135 basesExon 5: 99,793,892–99,793,999, 108 basesExon 6: 99,794,413–99,794,468, 56 basesExon 7: 99,797,097–99,797,331, 235 basesExon 8: 99,799,207–99,799,370, 164 basesExon 9: 99,800,386–99,800,563, 178 basesExon 10: 99,804,019–99,804,273, 255 basesExon 11: 99,805,382–99,805,447, 66 basesExon 12: 99,807,384–99,807,521, 138 basesExon 13: 99,808,083–99,808,229, 147 basesExon 14: 99,810,134–99,810,218, 85 basesExon 15: 99,811,536–99,811,602, 67 basesExon 16: 99,813,018–99,813,144, 127 basesExon 17: 99,817,308–99,817,484, 177 basesExon 18: 99,818,790–99,818,957, 168 basesExon 19: 99,819,089–99,819,269, 181 basesExon 20: 99,830,307–99,830,433, 127 basesExon 21: 99,830,716–99,830,851, 136 basesExon 22: 99,831,611–99,831,830, 220 basesExon 23: 99,831,977–99,832,131, 155 basesExon 24: 99,834,380–99,834,535, 156 basesExon 25: 99,836,091–99,836,290, 200 basesExon 26: 99,841,967–99,842,093, 127 basesExon 27: 99,843,799–99,843,900, 102 basesExon 28: 99,844,322–99,844,465, 144 basesExon 29: 99,845,624–99,845,782, 159 basesExon 30: 99,846,961–99,847,127, 167 basesExon 31: 99,850,602–99,850,796, 195 basesExon 32: 99,851,502–99,852,594, 1,093 bases151015202530325′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.8 kb of the gene's 70 kb; 4,638 of those bases code for the protein.

How a genome test reads ABCC2

62

positions in ABCC2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 70 kb of ABCC2, introns included, not only the 5.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ABCC2 gene: ATP binding cassette subfamily C member 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/abcc2

Vancouver

Dante Labs. ABCC2 gene: ATP binding cassette subfamily C member 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/abcc2

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