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Gene

KIF12

kinesin family member 12

Summary

Cytogenetic location
9q32
Coordinates
Chromosome 9: 114,091,638–114,099,292 (GRCh38)
Exons
19 exons across 7.7 kb
Protein
651 amino acids
Inheritance
Autosomal recessive
MANE Select transcript
ENST00000640217.2NM_001388308.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Familial Intrahepatic Cholestasis

    • Autosomal recessive

      An instance of intrahepatic cholestasis that is caused by an inherited modification of the individual's genome.

      • 2 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How KIF12 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 9, with a bracket where KIF12 sits. KIF12 and 9 genes near it on chromosome 9, from 113,595,465 to 114,595,464.Chromosome 99q32p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.3113.6 Mb113.8 Mb114 Mb114.2 Mb114.4 MbRGS3: 113,444,731–113,597,743, forward strandRGS3ZNF618: 113,876,052–114,056,593, forward strandZNF618AMBP: 114,060,127–114,080,970, reverse strandAMBPKIF12: 114,091,638–114,099,292, reverse strandKIF12COL27A1: 114,155,486–114,312,511, forward strandCOL27A1ORM1: 114,322,951–114,326,970, forward strandORM1ORM2: 114,329,777–114,333,741, forward strandORM2AKNA: 114,334,156–114,394,405, reverse strandAKNAWHRN: 114,402,078–114,505,530, reverse strandWHRNATP6V1G1: 114,587,572–114,598,915, forward strandATP6V1G1Diagram of KIF12: 19 exons on the reverse strand of chromosome 9Exon 18: 1 known disease-causing siteExon 17: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 19: 114,091,638–114,092,000, 363 basesExon 18: 114,092,333–114,092,451, 119 basesExon 17: 114,092,542–114,092,642, 101 basesExon 16: 114,093,229–114,093,333, 105 basesExon 15: 114,093,407–114,093,497, 91 basesExon 14: 114,093,886–114,093,972, 87 basesExon 13: 114,094,181–114,094,271, 91 basesExon 12: 114,094,353–114,094,455, 103 basesExon 11: 114,095,023–114,095,127, 105 basesExon 10: 114,095,214–114,095,332, 119 basesExon 9: 114,096,051–114,096,207, 157 basesExon 8: 114,096,387–114,096,478, 92 basesExon 7: 114,097,301–114,097,436, 136 basesExon 6: 114,097,607–114,097,741, 135 basesExon 5: 114,098,115–114,098,190, 76 basesExon 4: 114,098,302–114,098,429, 128 basesExon 3: 114,098,935–114,099,013, 79 basesExon 2: 114,099,104–114,099,169, 66 basesExon 1: 114,099,251–114,099,292, 42 bases191816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 7.7 kb; 1,956 of those bases code for the protein.

How a genome test reads KIF12

8

positions in KIF12 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 7.7 kb of KIF12, introns included, not only the 2.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KIF12 gene: kinesin family member 12. Retrieved 16 October 2026, from https://dantelabs.com/genes/kif12

Vancouver

Dante Labs. KIF12 gene: kinesin family member 12 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/kif12

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