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Gene

GLRX5

glutaredoxin 5

Summary

Cytogenetic location
14q32.13
Coordinates
Chromosome 14: 95,535,050–95,544,714 (GRCh38)
Exons
2 exons across 9.7 kb
Protein
157 amino acids
Also known as
PR01238, GRX5
Previous symbols
C14orf87
MANE Select transcript
ENST00000331334.5NM_016417.3
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Hereditary Sideroblastic Anaemias

    • Inherited Sideroblastic Anaemia

      A group of conditions caused by changes in genes such as ALAS2 and ABCB7 (X-linked), SLC25A38, GLRX5, PUS1, YARS2 and TRNT1 (recessive) and HSPA9 (dominant); some forms also affect the muscles, nervous system or immune system.

      • 3 GenCC submitters rate it definitive or strong
      Actionability

      The X-linked ALAS2 form often responds to vitamin B6 (pyridoxine), and a diagnosis guides iron-overload monitoring and distinguishes these conditions from acquired myelodysplastic syndrome.

How GLRX5 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where GLRX5 sits. GLRX5 and 7 genes near it on chromosome 14, from 95,039,882 to 96,039,881.Chromosome 1414q32.13p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3395.2 Mb95.4 Mb95.6 Mb95.8 Mb96 MbDICER1: 95,086,228–95,158,010, reverse strandDICER1CLMN: 95,181,940–95,320,058, reverse strandCLMNSYNE3: 95,407,266–95,516,854, reverse strandSYNE3GLRX5: 95,535,050–95,544,714, forward strandGLRX5TCL1B: 95,686,397–95,692,638, forward strandTCL1BTCL1A: 95,694,156–95,714,196, reverse strandTCL1ATUNAR: 95,866,587–95,925,871, forward strandTUNARC14orf132: 96,039,323–96,095,498, forward strandC14orf132Diagram of GLRX5: 2 exons on the forward strand of chromosome 14Exon 1: 2 known disease-causing sitesExon 2: 1 known disease-causing siteExon 1: 95,535,050–95,535,384, 335 basesExon 2: 95,543,947–95,544,714, 768 bases125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.1 kb of the gene's 9.7 kb; 474 of those bases code for the protein.

Sequencing GLRX5

3

positions in GLRX5 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 9.7 kb of GLRX5, introns included, not only the 1.1 kb of exons.

Genes linked to the same conditions

Traits linked to GLRX5

The Human Phenotype Ontology lists these as features of the rare conditions GLRX5 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). GLRX5 gene: glutaredoxin 5. Retrieved 17 October 2026, from https://dantelabs.com/genes/glrx5

Vancouver

Dante Labs. GLRX5 gene: glutaredoxin 5 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/glrx5

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