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Gene

ALDOB

aldolase, fructose-bisphosphate B

Summary

Cytogenetic location
9q31.1
Coordinates
Chromosome 9: 101,420,560–101,435,774 (GRCh38)
Exons
9 exons across 15.2 kb
Protein
364 amino acids
Inheritance
Autosomal recessive
MANE Select transcript
ENST00000647789.2NM_000035.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Fructose Intolerance & Gluconeogenesis Defects

    • Hereditary Fructose IntoleranceAutosomal recessive

      Caused by variants in ALDOB; eating fructose, sucrose or sorbitol can cause low blood sugar, vomiting and liver and kidney damage.

      • ClinGen rates the link definitive
      • 7 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing allows strict avoidance of fructose, sucrose and sorbitol, including in medicines and intravenous fluids, which prevents harm.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How ALDOB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 9, with a bracket where ALDOB sits. ALDOB and 8 genes near it on chromosome 9, from 100,928,167 to 101,928,166.Chromosome 99q31.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.3101 Mb101.2 Mb101.4 Mb101.6 Mb101.8 MbPLPPR1: 101,028,689–101,325,337, forward strandPLPPR1BAAT: 101,351,986–101,385,400, reverse strandBAATMRPL50: 101,386,116–101,398,665, reverse strandMRPL50ZNF189: 101,398,842–101,414,176, forward strandZNF189ALDOB: 101,420,560–101,435,774, reverse strandALDOBPGAP4: 101,470,915–101,533,537, reverse strandPGAP4RNF20: 101,533,821–101,563,348, forward strandRNF20GRIN3A: 101,569,352–101,738,654, reverse strandGRIN3APPP3R2: 101,591,604–101,595,021, reverse strandPPP3R2Diagram of ALDOB: 9 exons on the reverse strand of chromosome 9Exon 9: 5 known disease-causing sitesExon 8: 8 known disease-causing sitesExon 7: 13 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 5: 18 known disease-causing sitesExon 4: 5 known disease-causing sitesExon 3: 21 known disease-causing sitesExon 2: 7 known disease-causing sitesExon 9: 101,420,560–101,421,904, 1,345 basesExon 8: 101,424,843–101,425,042, 200 basesExon 7: 101,425,453–101,425,627, 175 basesExon 6: 101,426,555–101,426,638, 84 basesExon 5: 101,427,482–101,427,642, 161 basesExon 4: 101,428,469–101,428,523, 55 basesExon 3: 101,429,755–101,429,966, 212 basesExon 2: 101,430,776–101,430,897, 122 basesExon 1: 101,435,709–101,435,774, 66 bases9876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.4 kb of the gene's 15.2 kb; 1,095 of those bases code for the protein.

How a genome test reads ALDOB

98

positions in ALDOB where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 15.2 kb of ALDOB, introns included, not only the 2.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ALDOB gene: aldolase, fructose-bisphosphate B. Retrieved 16 October 2026, from https://dantelabs.com/genes/aldob

Vancouver

Dante Labs. ALDOB gene: aldolase, fructose-bisphosphate B [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/aldob

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