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Gene

HTRA2

HtrA serine peptidase 2

Summary

Cytogenetic location
2p13.1
Coordinates
Chromosome 2: 74,529,933–74,533,319 (GRCh38)
Exons
8 exons across 3.4 kb
Protein
458 amino acids
Also known as
OMI, PARK13
Previous symbols
PRSS25
MANE Select transcript
ENST00000258080.8NM_013247.5
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads HTRA2 yet. The test sequences your whole genome, so your data includes it all the same.

How HTRA2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 2, with a bracket where HTRA2 sits. HTRA2 and 29 genes near it on chromosome 2, from 74,031,626 to 75,031,625.Chromosome 22p13.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.374.2 Mb74.4 Mb74.6 Mb74.8 Mb75 MbTET3: 73,984,910–74,108,177, forward strandTET3BOLA3: 74,133,333–74,147,977, reverse strandBOLA3MOB1A: 74,152,528–74,178,932, reverse strandMOB1AMTHFD2: 74,186,172–74,218,432, forward strandMTHFD2: 74,211,604–74,363,377, reverse strandSLC4A5: 74,216,242–74,343,416, reverse strandSLC4A5DCTN1: 74,361,154–74,392,087, reverse strandDCTN1: 74,393,836–74,421,662, reverse strandC2orf81: 74,414,176–74,421,655, reverse strandWDR54: 74,421,477–74,425,770, forward strandWDR54RTKN: 74,424,131–74,442,422, reverse strandINO80B: 74,455,078–74,457,958, forward strandINO80B-WBP1: 74,455,088–74,460,884, forward strandWBP1: 74,458,263–74,461,077, forward strandMOGS: 74,461,057–74,465,415, reverse strandMOGSCCDC142: 74,471,957–74,483,408, reverse strandMRPL53: 74,471,957–74,472,699, reverse strandMRPL53TTC31: 74,482,617–74,496,915, forward strandLBX2: 74,497,455–74,503,316, reverse strandPCGF1: 74,505,041–74,508,361, reverse strandTLX2: 74,513,463–74,517,148, forward strandDQX1: 74,518,131–74,526,396, reverse strandDQX1AUP1: 74,526,636–74,529,966, reverse strandAUP1HTRA2: 74,529,933–74,533,319, forward strandHTRA2LOXL3: 74,531,716–74,555,718, reverse strandLOXL3DOK1: 74,548,875–74,557,554, forward strandM1AP: 74,557,883–74,648,350, reverse strandM1APSEMA4F: 74,654,226–74,707,584, forward strandSEMA4FHK2: 74,834,077–74,893,359, forward strandHK2POLE4: 74,958,636–75,147,205, forward strandPOLE4Diagram of HTRA2: 8 exons on the forward strand of chromosome 2Exon 1: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 1: 74,529,933–74,530,512, 580 basesExon 2: 74,530,617–74,530,821, 205 basesExon 3: 74,530,911–74,531,105, 195 basesExon 4: 74,531,339–74,531,371, 33 basesExon 5: 74,531,597–74,531,702, 106 basesExon 6: 74,531,856–74,531,925, 70 basesExon 7: 74,532,619–74,532,714, 96 basesExon 8: 74,532,820–74,533,319, 500 bases123456785′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.8 kb of the gene's 3.4 kb; 1,377 of those bases code for the protein.

Sequencing HTRA2

4

positions in HTRA2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3.4 kb of HTRA2, introns included, not only the 1.8 kb of exons.

Traits linked to HTRA2

The Human Phenotype Ontology lists these as features of the rare conditions HTRA2 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). HTRA2 gene: HtrA serine peptidase 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/htra2

Vancouver

Dante Labs. HTRA2 gene: HtrA serine peptidase 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/htra2

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