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Gene

ROS1

ROS proto-oncogene 1, receptor tyrosine kinase

Summary

Cytogenetic location
6q22.1
Coordinates
Chromosome 6: 117,287,353–117,425,942 (GRCh38)
Exons
44 exons across 138.6 kb
Protein
2,341 amino acids
Also known as
MCF3, ROS, c-ros-1
MANE Select transcript
ENST00000368507.8NM_001378902.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads ROS1 yet. The test sequences your whole genome, so your data includes it all the same.

How ROS1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 6, with a bracket where ROS1 sits. ROS1 and 6 genes near it on chromosome 6, from 116,856,648 to 117,856,647.Chromosome 66q22.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27117 Mb117.2 Mb117.4 Mb117.6 Mb117.8 MbRFX6: 116,877,212–116,933,069, forward strandRFX6VGLL2: 117,265,558–117,276,512, forward strandVGLL2ROS1: 117,287,353–117,425,942, reverse strandROS1: 117,318,211–117,573,571, reverse strandDCBLD1: 117,453,817–117,586,238, forward strandDCBLD1GOPC: 117,560,269–117,602,553, reverse strandGOPCNUS1: 117,675,469–117,710,727, forward strandNUS1Diagram of ROS1: 44 exons on the reverse strand of chromosome 6Exon 44: 117,287,353–117,288,802, 1,450 basesExon 43: 117,300,974–117,301,137, 164 basesExon 42: 117,308,794–117,308,928, 135 basesExon 41: 117,310,081–117,310,281, 201 basesExon 40: 117,311,020–117,311,117, 98 basesExon 39: 117,317,143–117,317,272, 130 basesExon 38: 117,318,188–117,318,252, 65 basesExon 37: 117,319,868–117,320,030, 163 basesExon 36: 117,321,259–117,321,394, 136 basesExon 35: 117,324,332–117,324,415, 84 basesExon 34: 117,326,224–117,326,414, 191 basesExon 33: 117,329,329–117,329,446, 118 basesExon 32: 117,337,172–117,337,340, 169 basesExon 31: 117,341,135–117,341,311, 177 basesExon 30: 117,341,400–117,341,632, 233 basesExon 29: 117,342,400–117,342,544, 145 basesExon 28: 117,344,060–117,344,262, 203 basesExon 27: 117,352,990–117,353,166, 177 basesExon 26: 117,356,629–117,356,915, 287 basesExon 25: 117,357,804–117,358,009, 206 basesExon 24: 117,359,809–117,360,011, 203 basesExon 23: 117,360,342–117,360,405, 64 basesExon 22: 117,362,603–117,362,865, 263 basesExon 21: 117,365,060–117,365,204, 145 basesExon 20: 117,365,581–117,365,741, 161 basesExon 19: 117,366,076–117,366,290, 215 basesExon 18: 117,379,059–117,379,159, 101 basesExon 17: 117,383,317–117,383,508, 192 basesExon 16: 117,385,683–117,385,861, 179 basesExon 15: 117,386,889–117,386,999, 111 basesExon 14: 117,387,780–117,387,992, 213 basesExon 13: 117,389,350–117,389,846, 497 basesExon 12: 117,393,224–117,393,321, 98 basesExon 11: 117,394,162–117,394,346, 185 basesExon 10: 117,394,616–117,394,738, 123 basesExon 9: 117,396,188–117,396,264, 77 basesExon 8: 117,396,915–117,397,116, 202 basesExon 7: 117,403,139–117,403,277, 139 basesExon 6: 117,404,280–117,404,428, 149 basesExon 5: 117,409,582–117,409,642, 61 basesExon 4: 117,414,519–117,414,545, 27 basesExon 3: 117,416,258–117,416,317, 60 basesExon 2: 117,418,462–117,418,506, 45 basesExon 1: 117,425,534–117,425,942, 409 bases4440353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8.5 kb of the gene's 138.6 kb; 7,026 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). ROS1 gene: ROS proto-oncogene 1, receptor tyrosine kinase. Retrieved 17 October 2026, from https://dantelabs.com/genes/ros1

Vancouver

Dante Labs. ROS1 gene: ROS proto-oncogene 1, receptor tyrosine kinase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ros1

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