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Gene

RHAG

Rh associated glycoprotein

Summary

Cytogenetic location
6p12.3
Coordinates
Chromosome 6: 49,605,175–49,636,839 (GRCh38)
Exons
10 exons across 31.7 kb
Protein
409 amino acids
Inheritance
Autosomal dominant
Also known as
RH50A, CD241, SLC42A1
MANE Select transcript
ENST00000371175.10NM_000324.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Red Blood Cell Membrane Disorders

    • Hereditary StomatocytosisAutosomal dominant

      A group of conditions in which red cells leak or gain water and salts, including dehydrated hereditary stomatocytosis (PIEZO1, KCNN4), overhydrated stomatocytosis (RHAG), Southeast Asian ovalocytosis and Rh-deficiency syndrome, causing haemolytic anaemia of varying severity and sometimes iron overload.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Spleen removal should be avoided because it raises the risk of serious blood clots in these conditions.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How RHAG is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where RHAG sits. RHAG and 12 genes near it on chromosome 6, from 49,121,007 to 50,121,006.Chromosome 66p12.3p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2749.2 Mb49.4 Mb49.6 Mb49.8 Mb50 MbMMUT: 49,430,360–49,463,321, reverse strandMMUTCENPQ: 49,463,335–49,495,815, forward strandCENPQGLYATL3: 49,499,923–49,528,078, forward strandGLYATL3C6orf141: 49,550,656–49,561,914, forward strandC6orf141RHAG: 49,605,175–49,636,839, reverse strandRHAGCRISP2: 49,692,358–49,714,703, reverse strandCRISP2CRISP3: 49,727,376–49,744,445, reverse strandCRISP3PGK2: 49,773,390–49,787,285, reverse strandPGK2CRISP1: 49,834,257–49,877,096, reverse strandCRISP1DEFB114: 49,960,249–49,964,164, reverse strandDEFB114DEFB113: 49,968,677–49,969,625, reverse strandDEFB113DEFB110: 50,009,138–50,021,994, reverse strandDEFB110DEFB112: 50,042,099–50,049,936, reverse strandDEFB112Diagram of RHAG: 10 exons on the reverse strand of chromosome 6Exon 6: 1 known disease-causing siteExon 10: 49,605,175–49,605,830, 656 basesExon 9: 49,606,848–49,606,921, 74 basesExon 8: 49,607,150–49,607,220, 71 basesExon 7: 49,611,024–49,611,145, 122 basesExon 6: 49,612,397–49,612,534, 138 basesExon 5: 49,614,687–49,614,853, 167 basesExon 4: 49,615,624–49,615,771, 148 basesExon 3: 49,618,068–49,618,218, 151 basesExon 2: 49,619,179–49,619,362, 184 basesExon 1: 49,636,656–49,636,839, 184 bases10864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 31.7 kb; 1,230 of those bases code for the protein.

How a genome test reads RHAG

3

positions in RHAG where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 31.7 kb of RHAG, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RHAG gene: Rh associated glycoprotein. Retrieved 17 October 2026, from https://dantelabs.com/genes/rhag

Vancouver

Dante Labs. RHAG gene: Rh associated glycoprotein [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rhag

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