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Gene

TMEM63B

transmembrane protein 63B

Summary

Cytogenetic location
6p21.1
Coordinates
Chromosome 6: 44,127,554–44,155,519 (GRCh38)
Exons
24 exons across 28 kb
Protein
832 amino acids
Also known as
DKFZp434P0531, dJ421H19.2
Previous symbols
C6orf110
MANE Select transcript
ENST00000323267.11NM_018426.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • 1 GenCC submitter rates it definitive or strong

    How TMEM63B is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 6, with a bracket where TMEM63B sits. TMEM63B and 17 genes near it on chromosome 6, from 43,641,537 to 44,641,536.Chromosome 66p21.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2743.8 Mb44 Mb44.2 Mb44.4 Mb44.6 MbRSPH9: 43,644,229–43,674,358, forward strandRSPH9MRPS18A: 43,669,978–43,687,954, reverse strandMRPS18AVEGFA: 43,770,184–43,786,487, forward strandVEGFALINC03040: 44,000,580–44,007,830, forward strandLINC03040MRPL14: 44,078,275–44,134,339, reverse strandMRPL14TMEM63B: 44,127,554–44,155,519, forward strandTMEM63BCAPN11: 44,158,811–44,184,401, forward strandCAPN11MYMX: 44,192,822–44,218,236, forward strandMYMXSLC29A1: 44,219,245–44,243,425, forward strandSLC29A1HSP90AB1: 44,237,395–44,253,888, forward strandHSP90AB1SLC35B2: 44,253,872–44,257,890, reverse strandSLC35B2NFKBIE: 44,258,166–44,265,788, reverse strandNFKBIETMEM151B: 44,270,450–44,307,506, forward strand: 44,273,194–44,378,957, forward strandDRC5: 44,278,718–44,297,725, reverse strandDRC5AARS2: 44,298,726–44,313,376, reverse strandSPATS1: 44,342,650–44,380,179, forward strandSPATS1CDC5L: 44,387,547–44,450,924, forward strandCDC5LDiagram of TMEM63B: 24 exons on the forward strand of chromosome 6Exon 2: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 1: 44,127,554–44,127,678, 125 basesExon 2: 44,134,561–44,134,743, 183 basesExon 3: 44,135,017–44,135,096, 80 basesExon 4: 44,135,328–44,135,366, 39 basesExon 5: 44,136,349–44,136,439, 91 basesExon 6: 44,138,480–44,138,517, 38 basesExon 7: 44,139,467–44,139,609, 143 basesExon 8: 44,139,708–44,139,759, 52 basesExon 9: 44,140,252–44,140,360, 109 basesExon 10: 44,141,028–44,141,098, 71 basesExon 11: 44,146,847–44,146,927, 81 basesExon 12: 44,147,377–44,147,500, 124 basesExon 13: 44,148,252–44,148,385, 134 basesExon 14: 44,148,513–44,148,650, 138 basesExon 15: 44,148,792–44,148,945, 154 basesExon 16: 44,149,859–44,149,965, 107 basesExon 17: 44,150,224–44,150,310, 87 basesExon 18: 44,150,564–44,150,629, 66 basesExon 19: 44,151,846–44,152,008, 163 basesExon 20: 44,152,593–44,152,698, 106 basesExon 21: 44,153,676–44,153,843, 168 basesExon 22: 44,154,073–44,154,188, 116 basesExon 23: 44,154,365–44,154,445, 81 basesExon 24: 44,154,692–44,155,519, 828 bases1246810121416182022245′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 3.3 kb of the gene's 28 kb; 2,499 of those bases code for the protein.

    How a genome test reads TMEM63B

    2

    positions in TMEM63B where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 28 kb of TMEM63B, introns included, not only the 3.3 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). TMEM63B gene: transmembrane protein 63B. Retrieved 17 October 2026, from https://dantelabs.com/genes/tmem63b

    Vancouver

    Dante Labs. TMEM63B gene: transmembrane protein 63B [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tmem63b

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