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Gene

TNPO3

transportin 3

Summary

Cytogenetic location
7q32.1
Coordinates
Chromosome 7: 128,954,185–129,055,111 (GRCh38)
Exons
23 exons across 100.9 kb
Protein
923 amino acids
Also known as
TRN-SR, MTR10A, TRN-SR2, IPO12
Previous symbols
LGMD1F
MANE Select transcript
ENST00000265388.10NM_012470.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Limb-Girdle Muscular Dystrophy

    • Limb-girdle Muscular Dystrophy is defined as a collection of numerous subtypes with differing inheritance patterns (with diagnostic sufficiency being varied too). Carriers of variants related to the condition should seek guidance from a muscular-skeletal specialist for a definitive diagnosis.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

How TNPO3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 7, with a bracket where TNPO3 sits. TNPO3 and 16 genes near it on chromosome 7, from 128,504,648 to 129,504,647.Chromosome 77q32.1p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3128.6 Mb128.8 Mb129 Mb129.2 Mb129.4 MbMETTL2B: 128,476,729–128,506,602, forward strandMETTL2BGARIN1A: 128,671,693–128,687,877, forward strandGARIN1AGARIN1B: 128,709,061–128,731,743, forward strandGARIN1BCALU: 128,739,292–128,773,400, forward strandCALUOPN1SW: 128,771,755–128,775,794, reverse strandOPN1SWCCDC136: 128,790,750–128,822,135, forward strandCCDC136FLNC: 128,830,292–128,859,275, forward strandFLNCKCP: 128,862,042–128,910,719, reverse strandKCPATP6V1F: 128,862,816–128,865,849, forward strandATP6V1FSPMIP1: 128,866,330–128,872,047, forward strandSPMIP1IRF5: 128,933,429–128,950,389, forward strandIRF5TNPO3: 128,954,185–129,055,111, reverse strandTNPO3TSPAN33: 129,144,690–129,177,456, forward strandTSPAN33SMO: 129,188,501–129,213,546, forward strandSMOAHCYL2: 129,225,020–129,431,841, forward strandAHCYL2STRIP2: 129,434,392–129,488,399, forward strandSTRIP2SMKR1: 129,502,498–129,512,918, forward strandSMKR1Diagram of TNPO3: 23 exons on the reverse strand of chromosome 7Exon 22: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 23: 128,954,185–128,955,385, 1,201 basesExon 22: 128,957,224–128,957,315, 92 basesExon 21: 128,967,280–128,967,392, 113 basesExon 20: 128,970,148–128,970,315, 168 basesExon 19: 128,972,426–128,972,582, 157 basesExon 18: 128,974,868–128,974,962, 95 basesExon 17: 128,975,819–128,975,935, 117 basesExon 16: 128,978,983–128,979,123, 141 basesExon 15: 128,979,971–128,980,031, 61 basesExon 14: 128,982,248–128,982,324, 77 basesExon 13: 128,984,168–128,984,259, 92 basesExon 12: 128,986,729–128,986,920, 192 basesExon 11: 128,989,961–128,990,100, 140 basesExon 10: 128,991,999–128,992,090, 92 basesExon 9: 128,993,807–128,993,914, 108 basesExon 8: 128,997,389–128,997,535, 147 basesExon 7: 129,000,429–129,000,567, 139 basesExon 6: 129,001,059–129,001,234, 176 basesExon 5: 129,005,016–129,005,159, 144 basesExon 4: 129,014,979–129,015,135, 157 basesExon 3: 129,016,983–129,017,056, 74 basesExon 2: 129,017,957–129,018,157, 201 basesExon 1: 129,054,651–129,055,111, 461 bases2322201816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.3 kb of the gene's 100.9 kb; 2,772 of those bases code for the protein.

How a genome test reads TNPO3

5

positions in TNPO3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 100.9 kb of TNPO3, introns included, not only the 4.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TNPO3 gene: transportin 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/tnpo3

Vancouver

Dante Labs. TNPO3 gene: transportin 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tnpo3

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