Gene
SLCO1B1
solute carrier organic anion transporter family member 1B1
- HGNC 10959(opens in a new tab)
- Ensembl gene ENSG00000134538(opens in a new tab)
- NCBI Gene 10599(opens in a new tab)
Summary
- Cytogenetic location
- 12p12.1
- Coordinates
- Chromosome 12: 21,131,194–21,239,796 (GRCh38)
- Exons
- 15 exons across 108.6 kb
- Protein
- 691 amino acids
- Also known as
- OATP-C, LST-1, OATP1B1
- Previous symbols
- SLC21A6
- MANE Select transcript
- ENST00000256958.3NM_006446.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Statin myopathy risk
Pharmacogenomics
SLCO1B1 transports statins into the liver. Reduced-function alleles raise blood statin levels and the risk of muscle side effects — most pronounced with simvastatin, but CPIC also gives guidance for atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin and rosuvastatin.
- If you take or start a statin and develop muscle aches, mention this result to your prescriber.
- The risk is largest for simvastatin. CPIC sets a dose limit for each statin, so a lower dose or a different statin is usually enough.
Alleles the report reads
- *5No function
- *1Normal function
Results CPIC describes
- Possible Decreased Function
- Decreased Function
- Increased Function
- Indeterminate
- Normal Function
- Poor Function
Medicine CPIC level Guideline atorvastatin A SLCO1B1, ABCG2, CYP2C9, and Statins fluvastatin A SLCO1B1, ABCG2, CYP2C9, and Statins lovastatin A SLCO1B1, ABCG2, CYP2C9, and Statins pitavastatin A SLCO1B1, ABCG2, CYP2C9, and Statins pravastatin A SLCO1B1, ABCG2, CYP2C9, and Statins rosuvastatin A SLCO1B1, ABCG2, CYP2C9, and Statins simvastatin A SLCO1B1, ABCG2, CYP2C9, and Statins Show 2 more medicines
Medicine CPIC level Guideline elagolix B/C methotrexate C
How SLCO1B1 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 2.8 kb of the gene's 108.6 kb; 2,076 of those bases code for the protein.
How a genome test reads SLCO1B1
6
positions in SLCO1B1 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 108.6 kb of SLCO1B1, introns included, not only the 2.8 kb of exons.
Traits linked to SLCO1B1
The Human Phenotype Ontology lists these as features of the rare conditions SLCO1B1 can cause. Each trait's page lists the other genes linked to it.
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- CPIC and PharmGKB: the alleles, results and medicines.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). SLCO1B1 gene: solute carrier organic anion transporter family member 1B1. Retrieved 16 October 2026, from https://dantelabs.com/genes/slco1b1
Dante Labs. SLCO1B1 gene: solute carrier organic anion transporter family member 1B1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/slco1b1
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