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Traits
Traits linked to STAT4
signal transducer and activator of transcription 4
The Human Phenotype Ontology links 191 traits to STAT4, by body system: features seen in people with one of the gene's rare conditions.
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Abnormality of the immune system
Abnormality of the nervous system
| Trait | How often it is seen |
|---|---|
| Migraine | Very often (80–99%) |
| Abnormal gait | Often (30–79%) |
| Confusion | Often (30–79%) |
| Headache | Often (30–79%) |
| Weakness of one side of body | Often (30–79%) |
| Abnormal pyramidal sign | Sometimes (5–29%) |
| Abnormality of the nervous system | Sometimes (5–29%) |
| Ataxia | Sometimes (5–29%) |
| Behavioral abnormality | Sometimes (5–29%) |
| Cranial nerve paralysis | Sometimes (5–29%) |
| Depression | Sometimes (5–29%) |
| Disturbances of consciousness | Sometimes (5–29%) |
| Epilepsy | Sometimes (5–29%) |
| Increased reflexes | Sometimes (5–29%) |
| Irritability | Sometimes (5–29%) |
| Loss of developmental milestones | Sometimes (5–29%) |
| Memory impairment | Sometimes (5–29%) |
| Paralysis on one side of body | Sometimes (5–29%) |
| Pins and needles feeling | Sometimes (5–29%) |
| Psychosis | Sometimes (5–29%) |
| Rise in pressure inside skull | Sometimes (5–29%) |
| Chorea | Rarely (1–4%) |
| Cognitive impairment | Rarely (1–4%) |
| Language impairment | Rarely (1–4%) |
Abnormality of the cardiovascular system
| Trait | How often it is seen |
|---|---|
| Inflammation of blood vessel | Very often (80–99%) |
| Fluid around heart | Often (30–79%) |
| High blood pressure | Often (30–79%) |
| Raynaud phenomenon | Often (30–79%) |
| Swollen lymph nodes | Often (30–79%) |
| Abnormal myocardium morphology | Sometimes (5–29%) |
| Aortic regurgitation | Sometimes (5–29%) |
| Blood clot in artery of lung | Sometimes (5–29%) |
| Disruption of blood oxygen supply to brain | Sometimes (5–29%) |
| Endocarditis | Sometimes (5–29%) |
| Heart attack | Sometimes (5–29%) |
| Increased spleen size | Sometimes (5–29%) |
| Inflammation of heart muscle | Sometimes (5–29%) |
| Mitral regurgitation | Sometimes (5–29%) |
| Swelling or irritation of membrane around heart | Sometimes (5–29%) |
| Enlarged liver and spleen | Rarely (1–4%) |
Abnormality of the musculoskeletal system
| Trait | How often it is seen |
|---|---|
| Arthritis | Very often (80–99%) |
| Oligoarthritis | Very often (80–99%) |
| Double-Jointed | Often (30–79%) |
| Enthesitis | Often (30–79%) |
| Joint contracture | Often (30–79%) |
| Joint stiffness | Often (30–79%) |
| Polyarticular arthritis | Often (30–79%) |
| Synovial lining hyperplasia | Often (30–79%) |
| Synovitis | Often (30–79%) |
| Abnormal cervical spine | Sometimes (5–29%) |
| Abnormality of the shoulder | Sometimes (5–29%) |
| Death of bone due to decreased blood supply | Sometimes (5–29%) |
| Flexed joint that cannot be straightened | Sometimes (5–29%) |
| Hip osteoarthritis | Sometimes (5–29%) |
| Muscle weakness | Sometimes (5–29%) |
| Rheumatoid arthritis | Sometimes (5–29%) |
Abnormality of the eye
| Trait | How often it is seen |
|---|---|
| Extreme sensitivity of the eyes to light | Very often (80–99%) |
| Nongranulomatous uveitis | Often (30–79%) |
| Panuveitis | Often (30–79%) |
| Uveitis | Often (30–79%) |
| Anterior chamber synechiae | Sometimes (5–29%) |
| Band keratopathy | Sometimes (5–29%) |
| Blindness | Sometimes (5–29%) |
| Clouding of the lens of the eye | Sometimes (5–29%) |
| Decreased clarity of vision | Sometimes (5–29%) |
| Noninflammatory retina disease | Sometimes (5–29%) |
| Optic neuritis | Sometimes (5–29%) |
| Retrobulbar optic neuritis | Sometimes (5–29%) |
| Visual loss | Sometimes (5–29%) |
| Glaucoma | Rarely (1–4%) |
| Iridocyclitis | Rarely (1–4%) |
Laboratory abnormality
| Trait | How often it is seen |
|---|---|
| Fever | Very often (80–99%) |
| High ESR | Very often (80–99%) |
| High urine protein levels | Very often (80–99%) |
| Blood in urine | Often (30–79%) |
| Elevated circulating C-reactive protein concentration | Often (30–79%) |
| Fluid around lungs | Often (30–79%) |
| Fluid retention | Often (30–79%) |
| High urine neutrophil count | Often (30–79%) |
| Increased circulating lactate dehydrogenase concentration | Often (30–79%) |
| Joint swelling | Often (30–79%) |
| AA amyloidosis | Sometimes (5–29%) |
| Dark urine | Sometimes (5–29%) |
| Episodic fever | Sometimes (5–29%) |
| Low-grade fever | Sometimes (5–29%) |
Abnormality of blood and blood-forming tissues
| Trait | How often it is seen |
|---|---|
| Blood clot in vein | Often (30–79%) |
| Decreased blood leukocyte number | Often (30–79%) |
| Decreased blood lymphocyte number | Often (30–79%) |
| Gastrointestinal bleeding | Often (30–79%) |
| Low blood neutrophil count | Often (30–79%) |
| Low platelet count | Often (30–79%) |
| Microangiopathic hemolytic anemia | Often (30–79%) |
| Superficial thrombophlebitis | Often (30–79%) |
| Blood clot in artery | Sometimes (5–29%) |
| Hemolytic anemia | Sometimes (5–29%) |
| Low number of red blood cells or hemoglobin | Sometimes (5–29%) |
Abnormality of the digestive system
| Trait | How often it is seen |
|---|---|
| Anorexia | Very often (80–99%) |
| Nausea and vomiting | Very often (80–99%) |
| Abdominal pain | Often (30–79%) |
| Abnormality of the gastrointestinal tract | Often (30–79%) |
| Abdominal bloating | Sometimes (5–29%) |
| Accumulation of fluid in the abdomen | Sometimes (5–29%) |
| Malabsorption | Sometimes (5–29%) |
| Pancreatic inflammation | Sometimes (5–29%) |
| Vomiting | Sometimes (5–29%) |
| Diarrhea | Rarely (1–4%) |
Abnormality of the genitourinary system
| Trait | How often it is seen |
|---|---|
| Inflammation of testicles | Very often (80–99%) |
| Genital ulcers | Often (30–79%) |
| Kidney inflammation | Often (30–79%) |
| Lupus nephritis | Often (30–79%) |
| Nephrotic syndrome | Often (30–79%) |
| Renal failure | Often (30–79%) |
| Urinary tract abnormalities | Often (30–79%) |
| Epididymitis | Sometimes (5–29%) |
| Glomerulopathy | Sometimes (5–29%) |
| Glomerulonephritis | Rarely (1–4%) |
Abnormality of the integument
| Trait | How often it is seen |
|---|---|
| Morphea | Always |
| Open skin sore | Always |
| Firm lump under the skin | Very often (80–99%) |
| Papule | Very often (80–99%) |
| Abnormal blistering of the skin | Often (30–79%) |
| Abnormality of the skin | Often (30–79%) |
| Hair loss | Often (30–79%) |
| Positive pathergy test | Often (30–79%) |
| Photosensitive skin | Sometimes (5–29%) |
| Squamous cell carcinoma of the skin | Sometimes (5–29%) |
Abnormality of limbs
| Trait | How often it is seen |
|---|---|
| Abnormality of the ankle | Often (30–79%) |
| Abnormality of the wrist | Often (30–79%) |
| Ankle swelling | Often (30–79%) |
| Knee osteoarthritis | Often (30–79%) |
| Abnormality of the hand | Sometimes (5–29%) |
| Abnormality of the hip joint | Sometimes (5–29%) |
| Abnormality of the knuckle | Sometimes (5–29%) |
| Abnormality of the long bone of foot | Sometimes (5–29%) |
Abnormality of head or neck
| Trait | How often it is seen |
|---|---|
| Mouth sore | Always |
| Recurrent canker sores | Very often (80–99%) |
| Abnormal color of the oral mucosa | Sometimes (5–29%) |
| Abnormality of salivation | Sometimes (5–29%) |
| Abnormality of the jaw joint | Sometimes (5–29%) |
| Dry eye syndrome | Sometimes (5–29%) |
| Inflammation of the lips | Sometimes (5–29%) |
Constitutional symptom
| Trait | How often it is seen |
|---|---|
| Fatigue | Very often (80–99%) |
| Malaise | Very often (80–99%) |
| Muscle ache | Very often (80–99%) |
| Joint pain | Often (30–79%) |
| Death of body tissue due to lack of blood flow or infection | Sometimes (5–29%) |
| Chest pain | Rarely (1–4%) |
Abnormality of the respiratory system
| Trait | How often it is seen |
|---|---|
| Abnormality of the respiratory system | Sometimes (5–29%) |
| Breathing difficulty | Sometimes (5–29%) |
| Coughing up blood | Sometimes (5–29%) |
| Inflammation of tissues lining lungs and chest | Sometimes (5–29%) |
| Lung infiltrates | Sometimes (5–29%) |
Growth abnormality
| Trait | How often it is seen |
|---|---|
| Weight loss | Very often (80–99%) |
| Faltering weight | Often (30–79%) |
| Mild growth deficiency | Sometimes (5–29%) |
| Severe growth delay in children | Sometimes (5–29%) |
Abnormality of the ear
| Trait | How often it is seen |
|---|---|
| Dizziness | Sometimes (5–29%) |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to STAT4 and how often each is seen. Find out more at hpo.jax.org.
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