Egenskaper

Egenskaper kopplade till STAT4

signal transducer and activator of transcription 4

Human Phenotype Ontology kopplar 191 egenskaper till STAT4, sorterade efter kroppssystem: drag som ses hos personer med ett av genens sällsynta tillstånd.

Abnormality of the immune system

Egenskap	Hur ofta den förekommer
Antinuclear antibody positivity	Mycket ofta (80–99 %)
Decreased circulating complement C3 concentration	Mycket ofta (80–99 %)
Decreased circulating complement C4 concentration	Mycket ofta (80–99 %)
Meningitis	Mycket ofta (80–99 %)
Abnormal circulating interleukin concentration	Ofta (30–79 %)
Acne	Ofta (30–79 %)
Anti-complement component C1q antibody positivity	Ofta (30–79 %)
Anti-ribosome Po antibody positivity	Ofta (30–79 %)
Anti-titin antibody positivity	Ofta (30–79 %)
Antineutrophil antibody positivity	Ofta (30–79 %)
Antiphospholipid antibody positivity	Ofta (30–79 %)
Autoimmunity	Ofta (30–79 %)
Erythema nodosum	Ofta (30–79 %)
Immunologic hypersensitivity	Ofta (30–79 %)
Increased circulating interferon-gamma concentration	Ofta (30–79 %)
Increased inflammatory response	Ofta (30–79 %)
Malar rash	Ofta (30–79 %)
Pimple	Ofta (30–79 %)
Recurrent infections	Ofta (30–79 %)
Skin rash	Ofta (30–79 %)
Anti-dsDNA antibody positivity	Ibland (5–29 %)
Anti-La/SS-B antibody positivity	Ibland (5–29 %)
Anti-nucleoporin 62 antibody positivity	Ibland (5–29 %)
Anti-phosphatidic acid antibody positivity	Ibland (5–29 %)
Anti-Ro52/TRIM21 antibody positivity	Ibland (5–29 %)
Anti-Sm antibody positivity	Ibland (5–29 %)
Anti-U1 ribonucleoprotein antibody positivity	Ibland (5–29 %)
Brain inflammation	Ibland (5–29 %)
Discoid lupus rash	Ibland (5–29 %)
Lupus anticoagulant	Ibland (5–29 %)
Muscle inflammation	Ibland (5–29 %)
Non-infectious meningitis	Ibland (5–29 %)
Serositis	Ibland (5–29 %)
Systemic lupus erythematosus	Ibland (5–29 %)

Abnormality of the nervous system

Egenskap	Hur ofta den förekommer
Migraine	Mycket ofta (80–99 %)
Abnormal gait	Ofta (30–79 %)
Confusion	Ofta (30–79 %)
Headache	Ofta (30–79 %)
Weakness of one side of body	Ofta (30–79 %)
Abnormal pyramidal sign	Ibland (5–29 %)
Abnormality of the nervous system	Ibland (5–29 %)
Ataxia	Ibland (5–29 %)
Behavioral abnormality	Ibland (5–29 %)
Cranial nerve paralysis	Ibland (5–29 %)
Depression	Ibland (5–29 %)
Disturbances of consciousness	Ibland (5–29 %)
Epilepsy	Ibland (5–29 %)
Increased reflexes	Ibland (5–29 %)
Irritability	Ibland (5–29 %)
Loss of developmental milestones	Ibland (5–29 %)
Memory impairment	Ibland (5–29 %)
Paralysis on one side of body	Ibland (5–29 %)
Pins and needles feeling	Ibland (5–29 %)
Psychosis	Ibland (5–29 %)
Rise in pressure inside skull	Ibland (5–29 %)
Chorea	Sällan (1–4%)
Cognitive impairment	Sällan (1–4%)
Language impairment	Sällan (1–4%)

Abnormality of the cardiovascular system

Egenskap	Hur ofta den förekommer
Inflammation of blood vessel	Mycket ofta (80–99 %)
Fluid around heart	Ofta (30–79 %)
High blood pressure	Ofta (30–79 %)
Raynaud phenomenon	Ofta (30–79 %)
Swollen lymph nodes	Ofta (30–79 %)
Abnormal myocardium morphology	Ibland (5–29 %)
Aortic regurgitation	Ibland (5–29 %)
Blood clot in artery of lung	Ibland (5–29 %)
Disruption of blood oxygen supply to brain	Ibland (5–29 %)
Endocarditis	Ibland (5–29 %)
Heart attack	Ibland (5–29 %)
Increased spleen size	Ibland (5–29 %)
Inflammation of heart muscle	Ibland (5–29 %)
Mitral regurgitation	Ibland (5–29 %)
Swelling or irritation of membrane around heart	Ibland (5–29 %)
Enlarged liver and spleen	Sällan (1–4%)

Abnormality of the musculoskeletal system

Egenskap	Hur ofta den förekommer
Arthritis	Mycket ofta (80–99 %)
Oligoarthritis	Mycket ofta (80–99 %)
Double-Jointed	Ofta (30–79 %)
Enthesitis	Ofta (30–79 %)
Joint contracture	Ofta (30–79 %)
Joint stiffness	Ofta (30–79 %)
Polyarticular arthritis	Ofta (30–79 %)
Synovial lining hyperplasia	Ofta (30–79 %)
Synovitis	Ofta (30–79 %)
Abnormal cervical spine	Ibland (5–29 %)
Abnormality of the shoulder	Ibland (5–29 %)
Death of bone due to decreased blood supply	Ibland (5–29 %)
Flexed joint that cannot be straightened	Ibland (5–29 %)
Hip osteoarthritis	Ibland (5–29 %)
Muscle weakness	Ibland (5–29 %)
Rheumatoid arthritis	Ibland (5–29 %)

Abnormality of the eye

Egenskap	Hur ofta den förekommer
Extreme sensitivity of the eyes to light	Mycket ofta (80–99 %)
Nongranulomatous uveitis	Ofta (30–79 %)
Panuveitis	Ofta (30–79 %)
Uveitis	Ofta (30–79 %)
Anterior chamber synechiae	Ibland (5–29 %)
Band keratopathy	Ibland (5–29 %)
Blindness	Ibland (5–29 %)
Clouding of the lens of the eye	Ibland (5–29 %)
Decreased clarity of vision	Ibland (5–29 %)
Noninflammatory retina disease	Ibland (5–29 %)
Optic neuritis	Ibland (5–29 %)
Retrobulbar optic neuritis	Ibland (5–29 %)
Visual loss	Ibland (5–29 %)
Glaucoma	Sällan (1–4%)
Iridocyclitis	Sällan (1–4%)

Laboratory abnormality

Egenskap	Hur ofta den förekommer
Fever	Mycket ofta (80–99 %)
High ESR	Mycket ofta (80–99 %)
High urine protein levels	Mycket ofta (80–99 %)
Blood in urine	Ofta (30–79 %)
Elevated circulating C-reactive protein concentration	Ofta (30–79 %)
Fluid around lungs	Ofta (30–79 %)
Fluid retention	Ofta (30–79 %)
High urine neutrophil count	Ofta (30–79 %)
Increased circulating lactate dehydrogenase concentration	Ofta (30–79 %)
Joint swelling	Ofta (30–79 %)
AA amyloidosis	Ibland (5–29 %)
Dark urine	Ibland (5–29 %)
Episodic fever	Ibland (5–29 %)
Low-grade fever	Ibland (5–29 %)

Abnormality of blood and blood-forming tissues

Egenskap	Hur ofta den förekommer
Blood clot in vein	Ofta (30–79 %)
Decreased blood leukocyte number	Ofta (30–79 %)
Decreased blood lymphocyte number	Ofta (30–79 %)
Gastrointestinal bleeding	Ofta (30–79 %)
Low blood neutrophil count	Ofta (30–79 %)
Low platelet count	Ofta (30–79 %)
Microangiopathic hemolytic anemia	Ofta (30–79 %)
Superficial thrombophlebitis	Ofta (30–79 %)
Blood clot in artery	Ibland (5–29 %)
Hemolytic anemia	Ibland (5–29 %)
Low number of red blood cells or hemoglobin	Ibland (5–29 %)

Abnormality of the digestive system

Egenskap	Hur ofta den förekommer
Anorexia	Mycket ofta (80–99 %)
Nausea and vomiting	Mycket ofta (80–99 %)
Abdominal pain	Ofta (30–79 %)
Abnormality of the gastrointestinal tract	Ofta (30–79 %)
Abdominal bloating	Ibland (5–29 %)
Accumulation of fluid in the abdomen	Ibland (5–29 %)
Malabsorption	Ibland (5–29 %)
Pancreatic inflammation	Ibland (5–29 %)
Vomiting	Ibland (5–29 %)
Diarrhea	Sällan (1–4%)

Abnormality of the genitourinary system

Egenskap	Hur ofta den förekommer
Inflammation of testicles	Mycket ofta (80–99 %)
Genital ulcers	Ofta (30–79 %)
Kidney inflammation	Ofta (30–79 %)
Lupus nephritis	Ofta (30–79 %)
Nephrotic syndrome	Ofta (30–79 %)
Renal failure	Ofta (30–79 %)
Urinary tract abnormalities	Ofta (30–79 %)
Epididymitis	Ibland (5–29 %)
Glomerulopathy	Ibland (5–29 %)
Glomerulonephritis	Sällan (1–4%)

Abnormality of the integument

Egenskap	Hur ofta den förekommer
Morphea	Alltid
Open skin sore	Alltid
Firm lump under the skin	Mycket ofta (80–99 %)
Papule	Mycket ofta (80–99 %)
Abnormal blistering of the skin	Ofta (30–79 %)
Abnormality of the skin	Ofta (30–79 %)
Hair loss	Ofta (30–79 %)
Positive pathergy test	Ofta (30–79 %)
Photosensitive skin	Ibland (5–29 %)
Squamous cell carcinoma of the skin	Ibland (5–29 %)

Abnormality of limbs

Egenskap	Hur ofta den förekommer
Abnormality of the ankle	Ofta (30–79 %)
Abnormality of the wrist	Ofta (30–79 %)
Ankle swelling	Ofta (30–79 %)
Knee osteoarthritis	Ofta (30–79 %)
Abnormality of the hand	Ibland (5–29 %)
Abnormality of the hip joint	Ibland (5–29 %)
Abnormality of the knuckle	Ibland (5–29 %)
Abnormality of the long bone of foot	Ibland (5–29 %)

Abnormality of head or neck

Egenskap	Hur ofta den förekommer
Mouth sore	Alltid
Recurrent canker sores	Mycket ofta (80–99 %)
Abnormal color of the oral mucosa	Ibland (5–29 %)
Abnormality of salivation	Ibland (5–29 %)
Abnormality of the jaw joint	Ibland (5–29 %)
Dry eye syndrome	Ibland (5–29 %)
Inflammation of the lips	Ibland (5–29 %)

Constitutional symptom

Egenskap	Hur ofta den förekommer
Fatigue	Mycket ofta (80–99 %)
Malaise	Mycket ofta (80–99 %)
Muscle ache	Mycket ofta (80–99 %)
Joint pain	Ofta (30–79 %)
Death of body tissue due to lack of blood flow or infection	Ibland (5–29 %)
Chest pain	Sällan (1–4%)

Abnormality of the respiratory system

Egenskap	Hur ofta den förekommer
Abnormality of the respiratory system	Ibland (5–29 %)
Breathing difficulty	Ibland (5–29 %)
Coughing up blood	Ibland (5–29 %)
Inflammation of tissues lining lungs and chest	Ibland (5–29 %)
Lung infiltrates	Ibland (5–29 %)

Growth abnormality

Egenskap	Hur ofta den förekommer
Weight loss	Mycket ofta (80–99 %)
Faltering weight	Ofta (30–79 %)
Mild growth deficiency	Ibland (5–29 %)
Severe growth delay in children	Ibland (5–29 %)

Abnormality of the ear

Egenskap	Hur ofta den förekommer
Dizziness	Ibland (5–29 %)

Hur ofta det förekommer hos personer med ett av genens tillstånd, den vanligaste frekvensen bland dem, enligt Human Phenotype Ontology. Dessa sidor beskriver egenskaper och forskningen bakom dem. De är inte en diagnos, och det är läkare eller genetisk rådgivare du bör fråga om symtom.

Varifrån informationen kommer

Human Phenotype Ontology, version 2026-09-01: egenskaperna som kopplas till STAT4 och hur ofta varje egenskap ses. Läs mer på hpo.jax.org.

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