Trait
Nephrotic syndrome
Nephrotic syndrome is a collection of findings resulting from glomerular dysfunction with an increase in glomerular capillary wall permeability associated with pronounced proteinuria. Nephrotic syndrome refers to the constellation of clinical findings that result from severe renal loss of protein, with Proteinuria and hypoalbuminemia, edema, and hyperlipidemia.
Summary
- Also called
- Nephrosis
- Body system
- Abnormality of the genitourinary system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test125 genes linked to Nephrotic syndrome
Changes in these genes cause rare conditions in which Nephrotic syndrome is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ARHGDIARho GDP dissociation inhibitor alpha | Always | In 1 condition |
| EMP2epithelial membrane protein 2 | Always | In 1 condition |
| FGAfibrinogen alpha chain | Always | In 1 condition |
| GSNgelsolin | Always | In 1 condition |
| ITGA3integrin subunit alpha 3 | Always | In 1 condition |
| JAK1Janus kinase 1 | Always | In 1 condition |
| KANK2KN motif and ankyrin repeat domains 2 | Always | In 1 condition |
| LAGE3L antigen family member 3 | Always | In 2 conditions |
| LAMA5laminin subunit alpha 5 | Always | In 1 condition |
| LAMB2laminin subunit beta 2 | Always | In 2 conditions |
| MYO1Emyosin IE | Always | In 1 condition |
| NOP10NOP10 ribonucleoprotein | Always | In 1 condition |
| NOS1APnitric oxide synthase 1 adaptor protein | Always | In 1 condition |
| NPHS1NPHS1 adhesion molecule, nephrin | Always | In 2 conditions |
| NPHS2NPHS2 stomatin family member, podocin | Always | In 1 condition |
| NUP133nucleoporin 133 | Always | In 2 conditions |
| PDSS2decaprenyl diphosphate synthase subunit 2 | Always | In 1 condition |
| PLCE1phospholipase C epsilon 1 | Always | In 1 condition |
| PRKCDprotein kinase C delta | Always | In 1 condition |
| PTPROprotein tyrosine phosphatase receptor type O | Always | In 1 condition |
| SCARB2scavenger receptor class B member 2 | Always | In 1 condition |
| SMARCAL1SNF2 related chromatin remodeling annealing helicase 1 | Always | In 1 condition |
| TBK1TANK binding kinase 1 | Always | In 1 condition |
| TP53RKTP53 regulating kinase | Always | In 2 conditions |
| WT1WT1 transcription factor | Always | In 6 conditions |
| FN1fibronectin 1 | Very often (80–99%) | In 2 conditions |
| GLAgalactosidase alpha | Very often (80–99%) | In 1 condition |
| GON7GON7 subunit of KEOPS complex | Very often (80–99%) | In 1 condition |
| MMEmembrane metalloendopeptidase | Very often (80–99%) | In 1 condition |
| NUP107nucleoporin 107 | Very often (80–99%) | In 3 conditions |
| OSGEPO-sialoglycoprotein endopeptidase | Very often (80–99%) | In 2 conditions |
| TPRKBTP53RK binding protein | Very often (80–99%) | In 1 condition |
| VPS33AVPS33A core subunit of CORVET and HOPS complexes | Very often (80–99%) | In 2 conditions |
| WDR4WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit | Very often (80–99%) | In 2 conditions |
| WDR73WD repeat domain 73 | Very often (80–99%) | In 3 conditions |
| YRDCyrdC N6-threonylcarbamoyltransferase domain containing | Very often (80–99%) | In 1 condition |
| CCND1cyclin D1 | Often (30–79%) | In 1 condition |
| DKC1dyskerin pseudouridine synthase 1 | Often (30–79%) | In 1 condition |
| IRAK1interleukin 1 receptor associated kinase 1 | Often (30–79%) | In 1 condition |
| NLRP3NLR family pyrin domain containing 3 | Often (30–79%) | In 1 condition |
Show 85 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SAA1serum amyloid A1 | Often (30–79%) | In 1 condition |
| SAT1spermidine/spermine N1-acetyltransferase 1 | Often (30–79%) | In 1 condition |
| SPP1secreted phosphoprotein 1 | Often (30–79%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Often (30–79%) | In 1 condition |
| STIM1stromal interaction molecule 1 | Often (30–79%) | In 1 condition |
| ZAP70zeta chain of T cell receptor associated protein kinase 70 | Often (30–79%) | In 2 conditions |
| ZNF592zinc finger protein 592 | Often (30–79%) | In 1 condition |
| ADAadenosine deaminase | Sometimes (5–29%) | In 1 condition |
| ALG1ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase | Sometimes (5–29%) | In 1 condition |
| ARL6ARF like GTPase 6 | Sometimes (5–29%) | In 1 condition |
| BBIP1BBSome interacting protein 1 | Sometimes (5–29%) | In 1 condition |
| BBS1Bardet-Biedl syndrome 1 | Sometimes (5–29%) | In 1 condition |
| BBS10Bardet-Biedl syndrome 10 | Sometimes (5–29%) | In 1 condition |
| BBS12Bardet-Biedl syndrome 12 | Sometimes (5–29%) | In 1 condition |
| BBS2Bardet-Biedl syndrome 2 | Sometimes (5–29%) | In 1 condition |
| BBS4Bardet-Biedl syndrome 4 | Sometimes (5–29%) | In 1 condition |
| BBS5Bardet-Biedl syndrome 5 | Sometimes (5–29%) | In 1 condition |
| BBS7Bardet-Biedl syndrome 7 | Sometimes (5–29%) | In 1 condition |
| BBS9Bardet-Biedl syndrome 9 | Sometimes (5–29%) | In 1 condition |
| C1QBPcomplement C1q binding protein | Sometimes (5–29%) | In 1 condition |
| CEP19centrosomal protein 19 | Sometimes (5–29%) | In 1 condition |
| CEP290centrosomal protein 290 | Sometimes (5–29%) | In 1 condition |
| CFAP418cilia and flagella associated protein 418 | Sometimes (5–29%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Sometimes (5–29%) | In 1 condition |
| COL4A3collagen type IV alpha 3 chain | Sometimes (5–29%) | In 3 conditions |
| CYBC1cytochrome b-245 chaperone 1 | Sometimes (5–29%) | In 1 condition |
| DCLRE1CDNA cross-link repair 1C | Sometimes (5–29%) | In 1 condition |
| DOCK11dedicator of cytokinesis 11 | Sometimes (5–29%) | In 1 condition |
| IFIH1interferon induced with helicase C domain 1 | Sometimes (5–29%) | In 1 condition |
| IFT172intraflagellar transport 172 | Sometimes (5–29%) | In 1 condition |
| IFT27intraflagellar transport 27 | Sometimes (5–29%) | In 1 condition |
| IFT74intraflagellar transport 74 | Sometimes (5–29%) | In 1 condition |
| IL2RGinterleukin 2 receptor subunit gamma | Sometimes (5–29%) | In 1 condition |
| IL7Rinterleukin 7 receptor | Sometimes (5–29%) | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Sometimes (5–29%) | In 2 conditions |
| LZTFL1leucine zipper transcription factor like 1 | Sometimes (5–29%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Sometimes (5–29%) | In 2 conditions |
| MKKSMKKS centrosomal shuttling protein | Sometimes (5–29%) | In 1 condition |
| MKS1MKS transition zone complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| NPHP1nephrocystin 1 | Sometimes (5–29%) | In 1 condition |
| NUDCD3NudC domain containing 3 | Sometimes (5–29%) | In 1 condition |
| PMM2phosphomannomutase 2 | Sometimes (5–29%) | In 2 conditions |
| PSMB10proteasome 20S subunit beta 10 | Sometimes (5–29%) | In 1 condition |
| PUS3pseudouridine synthase 3 | Sometimes (5–29%) | In 1 condition |
| RAG1recombination activating 1 | Sometimes (5–29%) | In 1 condition |
| RAG2recombination activating 2 | Sometimes (5–29%) | In 1 condition |
| RASA1RAS p21 protein activator 1 | Sometimes (5–29%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Sometimes (5–29%) | In 1 condition |
| SCAPERS-phase cyclin A associated protein in the ER | Sometimes (5–29%) | In 1 condition |
| SCLT1sodium channel and clathrin linker 1 | Sometimes (5–29%) | In 1 condition |
| SDCCAG8SHH signaling and ciliogenesis regulator SDCCAG8 | Sometimes (5–29%) | In 1 condition |
| SNAP29synaptosome associated protein 29 | Sometimes (5–29%) | In 1 condition |
| TRIM32tripartite motif containing 32 | Sometimes (5–29%) | In 1 condition |
| TRIM8tripartite motif containing 8 | Sometimes (5–29%) | In 1 condition |
| TTC8tetratricopeptide repeat domain 8 | Sometimes (5–29%) | In 1 condition |
| WDPCPWD repeat containing planar cell polarity effector | Sometimes (5–29%) | In 1 condition |
| ZNFX1zinc finger NFX1-type containing 1 | Sometimes (5–29%) | In 1 condition |
| COL4A5collagen type IV alpha 5 chain | Rarely (1–4%) | In 2 conditions |
| DHX37DEAH-box helicase 37 | Rarely (1–4%) | In 1 condition |
| FOXP3forkhead box P3 | Rarely (1–4%) | In 1 condition |
| GATA4GATA binding protein 4 | Rarely (1–4%) | In 1 condition |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Rarely (1–4%) | In 1 condition |
| MAP3K1mitogen-activated protein kinase kinase kinase 1 | Rarely (1–4%) | In 1 condition |
| MARS1methionyl-tRNA synthetase 1 | Rarely (1–4%) | In 1 condition |
| NR0B1nuclear receptor subfamily 0 group B member 1 | Rarely (1–4%) | In 1 condition |
| NR5A1nuclear receptor subfamily 5 group A member 1 | Rarely (1–4%) | In 1 condition |
| SOX9SRY-box transcription factor 9 | Rarely (1–4%) | In 1 condition |
| SRYsex determining region Y | Rarely (1–4%) | In 1 condition |
| VAMP7vesicle associated membrane protein 7 | Rarely (1–4%) | In 1 condition |
| WWOXWW domain containing oxidoreductase | Rarely (1–4%) | In 1 condition |
| ZFPM2zinc finger protein, FOG family member 2 | Rarely (1–4%) | In 1 condition |
| ANLNanillin, actin binding protein | Not recorded | In 1 condition |
| APTXaprataxin | Not recorded | In 1 condition |
| C3complement C3 | Not recorded | In 1 condition |
| CASP10caspase 10 | Not recorded | In 1 condition |
| CHST14carbohydrate sulfotransferase 14 | Not recorded | In 1 condition |
| COL4A4collagen type IV alpha 4 chain | Not recorded | In 2 conditions |
| COQ2coenzyme Q2, polyprenyltransferase | Not recorded | In 1 condition |
| DGKEdiacylglycerol kinase epsilon | Not recorded | In 1 condition |
| GATA3GATA binding protein 3 | Not recorded | In 1 condition |
| LMNB2lamin B2 | Not recorded | In 1 condition |
| PAX2paired box 2 | Not recorded | In 1 condition |
| SGPL1sphingosine-1-phosphate lyase 1 | Not recorded | In 1 condition |
| SLC17A5solute carrier family 17 member 5 | Not recorded | In 1 condition |
| TRPC6transient receptor potential cation channel subfamily C member 6 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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