Trait
Lupus nephritis
Lupus nephritis is a type of glomerulonephritis that constitutes one of the most severe organ manifestations of systemic lupus erythematosus. Lupus nephritis is subclassified in six distinct classes, that represent different manifestations and severities of renal involvement and guide the therapeutic management.
Summary
Reference genomeGRCh38hg38
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Get my Genome Test33 genes linked to Lupus nephritis
Changes in these genes cause rare conditions in which Lupus nephritis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| PLD4phospholipase D family member 4 | Always | In 1 condition |
| BANK1B cell scaffold protein with ankyrin repeats 1 | Often (30–79%) | In 1 condition |
| BLKBLK proto-oncogene, Src family tyrosine kinase | Often (30–79%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Often (30–79%) | In 1 condition |
| C4Bcomplement C4B (Chido/Rodgers blood group) | Often (30–79%) | In 1 condition |
| CR2complement C3d receptor 2 | Often (30–79%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Often (30–79%) | In 1 condition |
| DNASE1deoxyribonuclease 1 | Often (30–79%) | In 2 conditions |
| DNASE1L3deoxyribonuclease 1L3 | Often (30–79%) | In 1 condition |
| ETS1ETS proto-oncogene 1, transcription factor | Often (30–79%) | In 1 condition |
| FCGR2AFc gamma receptor IIa | Often (30–79%) | In 1 condition |
| FCGR2BFc gamma receptor IIb | Often (30–79%) | In 2 conditions |
| FCGR3BFc gamma receptor IIIb | Often (30–79%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Often (30–79%) | In 1 condition |
| IGHG1immunoglobulin heavy constant gamma 1 (G1m marker) | Often (30–79%) | In 1 condition |
| IL10interleukin 10 | Often (30–79%) | In 1 condition |
| IRAK1interleukin 1 receptor associated kinase 1 | Often (30–79%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Often (30–79%) | In 1 condition |
| ITGAMintegrin subunit alpha M | Often (30–79%) | In 1 condition |
| JAZF1JAZF zinc finger 1 | Often (30–79%) | In 1 condition |
| KIAA0319LKIAA0319 like | Often (30–79%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Often (30–79%) | In 1 condition |
| PDCD1programmed cell death 1 | Often (30–79%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Often (30–79%) | In 1 condition |
| PXKPX domain containing serine/threonine kinase like | Often (30–79%) | In 1 condition |
| SPP1secreted phosphoprotein 1 | Often (30–79%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Often (30–79%) | In 1 condition |
| TLR7toll like receptor 7 | Often (30–79%) | In 1 condition |
| TNFAIP3TNF alpha induced protein 3 | Often (30–79%) | In 1 condition |
| TNFSF4TNF superfamily member 4 | Often (30–79%) | In 1 condition |
| TNIP1TNFAIP3 interacting protein 1 | Often (30–79%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Often (30–79%) | In 2 conditions |
| UBE2L3ubiquitin conjugating enzyme E2 L3 | Often (30–79%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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