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Gene

NR3C1

nuclear receptor subfamily 3 group C member 1

Summary

Cytogenetic location
5q31.3
Coordinates
Chromosome 5: 143,277,934–143,403,686 (GRCh38)
Exons
9 exons across 125.8 kb
Protein
777 amino acids
Inheritance
Autosomal dominant
Also known as
GR
Previous symbols
GRL
MANE Select transcript
ENST00000394464.7NM_000176.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How NR3C1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 5, with a bracket where NR3C1 sits. NR3C1 and 2 genes near it on chromosome 5, from 142,840,810 to 143,840,809.Chromosome 55q31.3p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.3143 Mb143.2 Mb143.4 Mb143.6 Mb143.8 MbARHGAP26: 142,770,343–143,229,011, forward strandARHGAP26NR3C1: 143,277,934–143,403,686, reverse strandNR3C1HMHB1: 143,812,147–143,820,716, forward strandHMHB1Diagram of NR3C1: 9 exons on the reverse strand of chromosome 5Exon 9: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 9: 143,277,934–143,282,041, 4,108 basesExon 8: 143,282,568–143,282,725, 158 basesExon 7: 143,295,460–143,295,590, 131 basesExon 6: 143,298,668–143,298,812, 145 basesExon 5: 143,300,485–143,300,763, 279 basesExon 4: 143,310,097–143,310,213, 117 basesExon 3: 143,314,002–143,314,168, 167 basesExon 2: 143,399,656–143,400,852, 1,197 basesExon 1: 143,403,211–143,403,686, 476 bases9864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.8 kb of the gene's 125.8 kb; 2,334 of those bases code for the protein.

How a genome test reads NR3C1

6

positions in NR3C1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 125.8 kb of NR3C1, introns included, not only the 6.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NR3C1 gene: nuclear receptor subfamily 3 group C member 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/nr3c1

Vancouver

Dante Labs. NR3C1 gene: nuclear receptor subfamily 3 group C member 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nr3c1

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