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Gene

MRAP

melanocortin 2 receptor accessory protein

Summary

Cytogenetic location
21q22.11
Coordinates
Chromosome 21: 32,298,855–32,312,290 (GRCh38)
Exons
3 exons across 13.4 kb
Protein
172 amino acids
Inheritance
Autosomal recessive
Also known as
B27, FALP, MRAP1
Previous symbols
C21orf61
MANE Select transcript
ENST00000303645.10NM_001379228.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How MRAP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 21, with a bracket where MRAP sits. MRAP and 10 genes near it on chromosome 21, from 31,805,573 to 32,805,572.Chromosome 2121q22.11p13p12p11.2p11.1q11.1q11.2q21.1q21.2q21.3q22.11q22.12q22.13q22.2q22.332 Mb32.2 Mb32.4 Mb32.6 Mb32.8 MbHUNK: 31,872,805–32,044,633, forward strandHUNKMIS18A: 32,268,221–32,279,098, reverse strandMIS18AMRAP: 32,298,855–32,312,290, forward strandMRAPURB1: 32,311,018–32,393,042, reverse strandURB1CFAP298-TCP10L: 32,402,511–32,612,865, reverse strandCFAP298-TCP10LEVA1C: 32,411,692–32,517,158, forward strandEVA1CTCP10L: 32,497,967–32,587,373, reverse strandTCP10LCFAP298: 32,592,074–32,612,881, reverse strandCFAP298SYNJ1: 32,628,756–32,728,395, reverse strandSYNJ1PAXBP1: 32,733,899–32,771,854, reverse strandPAXBP1EPCIP: 32,790,673–32,813,743, reverse strandEPCIPDiagram of MRAP: 3 exons on the forward strand of chromosome 21Exon 1: 2 known disease-causing sitesExon 1: 32,298,855–32,299,077, 223 basesExon 2: 32,306,640–32,306,739, 100 basesExon 3: 32,311,684–32,312,290, 607 bases1235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.9 kb of the gene's 13.4 kb; 519 of those bases code for the protein.

How a genome test reads MRAP

3

positions in MRAP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 13.4 kb of MRAP, introns included, not only the 0.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MRAP gene: melanocortin 2 receptor accessory protein. Retrieved 16 October 2026, from https://dantelabs.com/genes/mrap

Vancouver

Dante Labs. MRAP gene: melanocortin 2 receptor accessory protein [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/mrap

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