Gene
LHCGR
luteinizing hormone/choriogonadotropin receptor
- HGNC 6585(opens in a new tab)
- Ensembl gene ENSG00000138039(opens in a new tab)
- NCBI Gene 3973(opens in a new tab)
Summary
- Cytogenetic location
- 2p16.3
- Coordinates
- Chromosome 2: 48,686,774–48,755,724 (GRCh38)
- Exons
- 11 exons across 69 kb
- Protein
- 699 amino acids
- Inheritance
- Autosomal dominant Autosomal recessive
- Also known as
- LHR, LCGR, LGR2, ULG5
- Previous symbols
- HHG
- MANE Select transcript
- ENST00000294954.12NM_000233.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome TestCurated reports relevant to this gene
46,XY Differences of Sex Development and Gonadal Dysgenesis
- Leydig cell hypoplasiaAutosomal recessive
A recessive condition caused by variants in LHCGR in which testosterone production is reduced, leading to undervirilisation in people with XY chromosomes.
- 2 GenCC submitters rate it definitive or strong
Monogenic Precocious Puberty
- Familial male-limited precocious pubertyAutosomal dominant
Early puberty in boys caused by activating LHCGR variants, independent of brain signals; female carriers are unaffected.
- 2 GenCC submitters rate it definitive or strong
What knowing changes
Treatment that blocks testosterone production or action can slow early puberty.
Inheritance
- Autosomal dominant
- One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.
- Autosomal recessive
- It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.
How LHCGR is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 3.1 kb of the gene's 69 kb; 2,100 of those bases code for the protein.
How a genome test reads LHCGR
25
positions in LHCGR where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 69 kb of LHCGR, introns included, not only the 3.1 kb of exons.
Traits linked to LHCGR
The Human Phenotype Ontology lists these as features of the rare conditions LHCGR can cause. Each trait's page lists the other genes linked to it.
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). LHCGR gene: luteinizing hormone/choriogonadotropin receptor. Retrieved 17 October 2026, from https://dantelabs.com/genes/lhcgr
Dante Labs. LHCGR gene: luteinizing hormone/choriogonadotropin receptor [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lhcgr
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