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Gene

NNT

nicotinamide nucleotide transhydrogenase

Summary

Cytogenetic location
5p12
Coordinates
Chromosome 5: 43,603,180–43,707,396 (GRCh38)
Exons
22 exons across 104.2 kb
Protein
1,086 amino acids
Inheritance
Autosomal recessive
MANE Select transcript
ENST00000344920.9NM_182977.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How NNT is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 5, with a bracket where NNT sits. NNT and 7 genes near it on chromosome 5, from 43,155,288 to 44,155,287.Chromosome 55p12p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.343.2 Mb43.4 Mb43.6 Mb43.8 Mb44 MbZBTB35: 43,065,176–43,192,021, forward strandZBTB35NIM1K: 43,192,071–43,280,862, forward strandNIM1KHMGCS1: 43,287,470–43,313,512, reverse strandHMGCS1CCL28: 43,376,642–43,412,392, reverse strandCCL28TMEM267: 43,444,249–43,484,476, reverse strandTMEM267C5orf34: 43,486,705–43,515,148, reverse strandC5orf34PAIP1: 43,526,267–43,557,758, reverse strandPAIP1NNT: 43,603,180–43,707,396, forward strandNNTDiagram of NNT: 22 exons on the forward strand of chromosome 5Exon 2: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 9: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 17: 1 known disease-causing siteExon 1: 43,603,180–43,603,294, 115 basesExon 2: 43,609,143–43,609,346, 204 basesExon 3: 43,612,908–43,613,137, 230 basesExon 4: 43,615,848–43,616,065, 218 basesExon 5: 43,619,032–43,619,119, 88 basesExon 6: 43,624,032–43,624,120, 89 basesExon 7: 43,628,200–43,628,387, 188 basesExon 8: 43,644,192–43,644,325, 134 basesExon 9: 43,644,611–43,644,802, 192 basesExon 10: 43,645,357–43,645,510, 154 basesExon 11: 43,649,147–43,649,308, 162 basesExon 12: 43,650,477–43,650,587, 111 basesExon 13: 43,651,739–43,651,884, 146 basesExon 14: 43,653,018–43,653,213, 196 basesExon 15: 43,655,840–43,656,073, 234 basesExon 16: 43,656,653–43,656,813, 161 basesExon 17: 43,659,171–43,659,350, 180 basesExon 18: 43,675,511–43,675,670, 160 basesExon 19: 43,677,725–43,677,806, 82 basesExon 20: 43,700,119–43,700,237, 119 basesExon 21: 43,702,621–43,702,736, 116 basesExon 22: 43,704,255–43,707,396, 3,142 bases15101520225′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.4 kb of the gene's 104.2 kb; 3,261 of those bases code for the protein.

How a genome test reads NNT

12

positions in NNT where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 104.2 kb of NNT, introns included, not only the 6.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NNT gene: nicotinamide nucleotide transhydrogenase. Retrieved 17 October 2026, from https://dantelabs.com/genes/nnt

Vancouver

Dante Labs. NNT gene: nicotinamide nucleotide transhydrogenase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nnt

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