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Gene

H6PD

hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase

Summary

Cytogenetic location
1p36.22
Coordinates
Chromosome 1: 9,234,774–9,271,337 (GRCh38)
Exons
5 exons across 36.6 kb
Protein
791 amino acids
Also known as
H6PDH
Previous symbols
GDH
MANE Select transcript
ENST00000377403.7NM_004285.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads H6PD yet. The test sequences your whole genome, so your data includes it all the same.

How H6PD is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where H6PD sits. H6PD and 11 genes near it on chromosome 1, from 8,753,056 to 9,753,055.Chromosome 11p36.22p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q448.8 Mb9 Mb9.2 Mb9.4 Mb9.6 MbRERE: 8,352,397–8,848,921, reverse strandREREENO1: 8,854,043–8,879,308, reverse strandENO1CA6: 8,945,867–8,975,092, forward strandCA6SLC2A7: 9,002,973–9,026,423, reverse strandSLC2A7SLC2A5: 9,035,106–9,088,478, reverse strandSLC2A5GPR157: 9,100,305–9,129,200, reverse strandGPR157H6PD: 9,234,774–9,271,337, forward strandH6PDSPSB1: 9,292,101–9,369,532, forward strandSPSB1SLC25A33: 9,539,437–9,585,173, forward strandSLC25A33TMEM201: 9,588,718–9,614,879, forward strandTMEM201PIK3CD: 9,629,889–9,730,119, forward strandPIK3CDCLSTN1: 9,728,911–9,823,993, reverse strandCLSTN1Diagram of H6PD: 5 exons on the forward strand of chromosome 1Exon 4: 1 known disease-causing siteExon 5: 2 known disease-causing sitesExon 1: 9,234,774–9,235,066, 293 basesExon 2: 9,244,925–9,245,561, 637 basesExon 3: 9,246,966–9,247,083, 118 basesExon 4: 9,262,059–9,262,328, 270 basesExon 5: 9,263,509–9,271,337, 7,829 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9.1 kb of the gene's 36.6 kb; 2,376 of those bases code for the protein.

How a genome test reads H6PD

3

positions in H6PD where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 36.6 kb of H6PD, introns included, not only the 9.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). H6PD gene: hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. Retrieved 16 October 2026, from https://dantelabs.com/genes/h6pd

Vancouver

Dante Labs. H6PD gene: hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/h6pd

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