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Gene

TNRC6B

trinucleotide repeat containing adaptor 6B

Summary

Cytogenetic location
22q13.1
Coordinates
Chromosome 22: 40,177,925–40,335,808 (GRCh38)
Exons
23 exons across 157.9 kb
Protein
1,833 amino acids
Also known as
KIAA1093
MANE Select transcript
ENST00000454349.7NM_001162501.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TNRC6B yet. The test sequences your whole genome, so your data includes it all the same.

How TNRC6B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 22, with a bracket where TNRC6B sits. TNRC6B and 9 genes near it on chromosome 22, from 39,756,867 to 40,756,866.Chromosome 2222q13.1p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3339.8 Mb40 Mb40.2 Mb40.4 Mb40.6 MbENTHD1: 39,743,044–39,893,864, reverse strandENTHD1GRAP2: 39,901,084–39,973,721, forward strandGRAP2TMA7B: 39,960,397–39,964,905, forward strandTMA7BSACK1F: 39,994,917–40,043,534, forward strandSACK1FTNRC6B: 40,177,925–40,335,808, forward strandTNRC6BADSL: 40,346,461–40,390,463, forward strandADSL: 40,346,529–40,410,054, forward strandSGSM3: 40,370,564–40,410,837, forward strandSGSM3MRTFA: 40,410,281–40,636,726, reverse strandMRTFAMCHR1: 40,679,273–40,682,812, forward strandMCHR1Diagram of TNRC6B: 23 exons on the forward strand of chromosome 22Exon 2: 1 known disease-causing siteExon 5: 23 known disease-causing sitesExon 6: 2 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 8: 1 known disease-causing siteExon 10: 2 known disease-causing sitesExon 13: 1 known disease-causing siteExon 17: 2 known disease-causing sitesExon 18: 1 known disease-causing siteExon 20: 1 known disease-causing siteExon 21: 1 known disease-causing siteExon 22: 1 known disease-causing siteExon 1: 40,177,925–40,178,140, 216 basesExon 2: 40,246,015–40,246,102, 88 basesExon 3: 40,251,179–40,251,200, 22 basesExon 4: 40,261,832–40,262,173, 342 basesExon 5: 40,264,688–40,267,036, 2,349 basesExon 6: 40,270,122–40,270,280, 159 basesExon 7: 40,273,425–40,273,600, 176 basesExon 8: 40,277,077–40,277,151, 75 basesExon 9: 40,277,999–40,278,044, 46 basesExon 10: 40,279,995–40,280,143, 149 basesExon 11: 40,281,119–40,281,289, 171 basesExon 12: 40,285,645–40,285,770, 126 basesExon 13: 40,300,455–40,300,586, 132 basesExon 14: 40,300,910–40,301,005, 96 basesExon 15: 40,301,150–40,301,333, 184 basesExon 16: 40,308,512–40,308,649, 138 basesExon 17: 40,310,817–40,310,993, 177 basesExon 18: 40,312,505–40,312,651, 147 basesExon 19: 40,312,902–40,312,997, 96 basesExon 20: 40,315,283–40,315,507, 225 basesExon 21: 40,315,942–40,316,012, 71 basesExon 22: 40,321,090–40,321,229, 140 basesExon 23: 40,322,854–40,335,808, 12,955 bases15101520235′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 18.3 kb of the gene's 157.9 kb; 5,502 of those bases code for the protein.

How a genome test reads TNRC6B

41

positions in TNRC6B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 157.9 kb of TNRC6B, introns included, not only the 18.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TNRC6B gene: trinucleotide repeat containing adaptor 6B. Retrieved 17 October 2026, from https://dantelabs.com/genes/tnrc6b

Vancouver

Dante Labs. TNRC6B gene: trinucleotide repeat containing adaptor 6B [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tnrc6b

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