Skip to content
Use your HSA or FSA funds

Gene

PDE11A

phosphodiesterase 11A

Summary

Cytogenetic location
2q31.2
Coordinates
Chromosome 2: 177,623,244–178,072,777 (GRCh38)
Exons
20 exons across 449.5 kb
Protein
933 amino acids
Inheritance
Autosomal dominant
MANE Select transcript
ENST00000286063.11NM_016953.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Carney Complex & Hereditary Adrenal Cushing Syndrome

    • Primary pigmented nodular adrenocortical diseaseAutosomal dominant

      Small pigmented adrenal nodules that produce cortisol independently of ACTH, causing Cushing syndrome, either alone or as part of Carney complex.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Biochemical screening for cortisol excess allows Cushing syndrome to be recognised and treated early.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How PDE11A is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where PDE11A sits. PDE11A and 11 genes near it on chromosome 2, from 177,173,710 to 178,522,311.Chromosome 22q31.2p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3177.2 Mb177.4 Mb177.6 Mb177.8 Mb178 Mb178.2 Mb178.4 MbHNRNPA3: 177,212,587–177,226,106, forward strandHNRNPA3NFE2L2: 177,218,667–177,392,756, reverse strandNFE2L2AGPS: 177,392,576–177,567,024, forward strandAGPSIFT70B: 177,548,998–177,552,796, reverse strandIFT70BIFT70A: 177,612,999–177,618,742, reverse strandIFT70APDE11A: 177,623,244–178,072,777, reverse strandPDE11ARBM45: 178,112,384–178,139,011, forward strandRBM45OSBPL6: 178,193,711–178,402,893, forward strandOSBPL6PRKRA: 178,431,292–178,451,512, reverse strandPRKRAPJVK: 178,451,346–178,462,408, forward strandPJVKFKBP7: 178,463,664–178,478,604, reverse strandFKBP7PLEKHA3: 178,480,347–178,516,463, forward strandPLEKHA3Diagram of PDE11A: 20 exons on the reverse strand of chromosome 2Exon 15: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 11: 2 known disease-causing sitesExon 8: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 1: 2 known disease-causing sitesExon 20: 177,623,244–177,629,562, 6,319 basesExon 19: 177,663,866–177,663,949, 84 basesExon 18: 177,669,493–177,669,567, 75 basesExon 17: 177,675,455–177,675,518, 64 basesExon 16: 177,680,826–177,680,903, 78 basesExon 15: 177,697,332–177,697,432, 101 basesExon 14: 177,701,121–177,701,211, 91 basesExon 13: 177,711,769–177,711,878, 110 basesExon 12: 177,727,658–177,727,765, 108 basesExon 11: 177,728,026–177,728,172, 147 basesExon 10: 177,769,323–177,769,373, 51 basesExon 9: 177,816,829–177,816,921, 93 basesExon 8: 177,817,858–177,817,925, 68 basesExon 7: 177,820,220–177,820,295, 76 basesExon 6: 177,840,251–177,840,383, 133 basesExon 5: 177,875,859–177,875,923, 65 basesExon 4: 177,898,058–177,898,198, 141 basesExon 3: 177,905,098–177,905,187, 90 basesExon 2: 178,014,302–178,014,460, 159 basesExon 1: 178,071,526–178,072,777, 1,252 bases201816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9.3 kb of the gene's 449.5 kb; 2,802 of those bases code for the protein.

How a genome test reads PDE11A

11

positions in PDE11A where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 449.5 kb of PDE11A, introns included, not only the 9.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PDE11A gene: phosphodiesterase 11A. Retrieved 17 October 2026, from https://dantelabs.com/genes/pde11a

Vancouver

Dante Labs. PDE11A gene: phosphodiesterase 11A [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/pde11a

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test