Skip to content
Use your HSA or FSA funds
Sequence your genome (opens in a new tab)

Gene

MORC2

MORC family CW-type zinc finger 2

Summary

Cytogenetic location
22q12.2
Coordinates
Chromosome 22: 30,925,130–30,968,774 (GRCh38)
Exons
26 exons across 43.6 kb
Protein
1,032 amino acids
Also known as
ZCW3, KIAA0852, AC004542.C22.1
Previous symbols
ZCWCC1
MANE Select transcript
ENST00000397641.8NM_001303256.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

    • Charcot-Marie-Tooth Disease

      • One of 62 genes linked to it

        A group of inherited peripheral neuropathies causing progressive weakness and wasting of the distal muscles and loss of sensation, mainly in the feet and hands.

        • ClinGen rates the link definitive
        • 3 GenCC submitters rate it definitive or strong
        What knowing changes

        Genetic counseling, subtype-specific monitoring, physical therapy, orthotics, neurotoxic drug avoidance, gene-specific clinical trials, surveillance for associated features

    How MORC2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 22, with a bracket where MORC2 sits. MORC2 and 20 genes near it on chromosome 22, from 30,446,952 to 31,446,951.Chromosome 2222q12.2p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3330.6 Mb30.8 Mb31 Mb31.2 Mb31.4 MbSEC14L3: 30,447,959–30,472,056, reverse strandSEC14L3SEC14L4: 30,488,890–30,505,725, reverse strandSEC14L4SEC14L6: 30,522,799–30,546,741, reverse strandSEC14L6GAL3ST1: 30,554,632–30,576,210, reverse strandGAL3ST1PES1: 30,576,624–30,607,083, reverse strandPES1TCN2: 30,607,003–30,630,712, forward strandTCN2SLC35E4: 30,635,673–30,669,016, forward strandSLC35E4DUSP18: 30,652,051–30,667,887, reverse strandDUSP18OSBP2: 30,693,782–30,907,824, forward strandOSBP2MORC2: 30,925,130–30,968,774, reverse strandMORC2TUG1: 30,969,245–30,979,413, forward strandTUG1SMTN: 31,064,105–31,104,757, forward strandSMTNSELENOM: 31,104,772–31,120,069, reverse strandSELENOMINPP5J: 31,122,731–31,134,697, forward strandINPP5JPLA2G3: 31,130,768–31,140,513, reverse strandPLA2G3RNF185: 31,160,149–31,207,019, forward strandRNF185LIMK2: 31,212,193–31,280,964, forward strandLIMK2PIK3IP1: 31,281,594–31,292,544, reverse strandPIK3IP1PATZ1: 31,325,804–31,346,605, reverse strandPATZ1DRG1: 31,399,515–31,528,740, forward strandDRG1EIF4ENIF1: 31,436,977–31,497,047, reverse strandEIF4ENIF1Diagram of MORC2: 26 exons on the reverse strand of chromosome 22Exon 26: 1 known disease-causing siteExon 15: 2 known disease-causing sitesExon 14: 8 known disease-causing sitesExon 13: 1 known disease-causing siteExon 9: 5 known disease-causing sitesExon 6: 3 known disease-causing sitesExon 5: 6 known disease-causing sitesExon 2: 3 known disease-causing sitesExon 1: 1 known disease-causing siteExon 26: 30,925,130–30,926,871, 1,742 basesExon 25: 30,928,019–30,928,207, 189 basesExon 24: 30,932,359–30,932,452, 94 basesExon 23: 30,932,545–30,932,769, 225 basesExon 22: 30,932,889–30,933,030, 142 basesExon 21: 30,933,466–30,933,520, 55 basesExon 20: 30,934,060–30,934,191, 132 basesExon 19: 30,934,781–30,935,161, 381 basesExon 18: 30,935,248–30,935,322, 75 basesExon 17: 30,936,511–30,936,643, 133 basesExon 16: 30,936,932–30,937,037, 106 basesExon 15: 30,937,583–30,937,711, 129 basesExon 14: 30,937,815–30,937,969, 155 basesExon 13: 30,938,065–30,938,205, 141 basesExon 12: 30,939,621–30,939,706, 86 basesExon 11: 30,939,959–30,940,041, 83 basesExon 10: 30,940,758–30,940,837, 80 basesExon 9: 30,941,433–30,941,558, 126 basesExon 8: 30,941,891–30,942,002, 112 basesExon 7: 30,942,112–30,942,271, 160 basesExon 6: 30,946,341–30,946,449, 109 basesExon 5: 30,949,752–30,949,842, 91 basesExon 4: 30,950,377–30,950,445, 69 basesExon 3: 30,956,763–30,956,797, 35 basesExon 2: 30,958,641–30,958,694, 54 basesExon 1: 30,967,822–30,968,774, 953 bases2625201510515′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 5.7 kb of the gene's 43.6 kb; 3,099 of those bases code for the protein.

    How a genome test reads MORC2

    30

    positions in MORC2 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 43.6 kb of MORC2, introns included, not only the 5.7 kb of exons.

    Genes linked to the same conditions

    Traits linked to MORC2

    The Human Phenotype Ontology lists these as features of the rare conditions MORC2 can cause. Each trait's page lists the other genes linked to it.

    Abnormality of the nervous system

    Show 45 more traits

    External links

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). MORC2 gene: MORC family CW-type zinc finger 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/morc2

    Vancouver

    Dante Labs. MORC2 gene: MORC family CW-type zinc finger 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/morc2

    One test. A lifetime of answers.

    From $449Free shipping · Results in 6–8 weeks

    Get my Genome Test