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Gene

SEMA4A

semaphorin 4A

Summary

Cytogenetic location
1q22
Coordinates
Chromosome 1: 156,153,585–156,177,744 (GRCh38)
Exons
15 exons across 24.2 kb
Protein
761 amino acids
Also known as
SemB, FLJ12287, CORD10
Previous symbols
SEMAB
MANE Select transcript
ENST00000368285.8NM_022367.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SEMA4A yet. The test sequences your whole genome, so your data includes it all the same.

How SEMA4A is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where SEMA4A sits. SEMA4A and 33 genes near it on chromosome 1, from 155,665,665 to 156,665,664.Chromosome 11q22p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44155.8 Mb156 Mb156.2 Mb156.4 Mb156.6 MbYY1AP1: 155,659,446–155,689,334, reverse strandYY1AP1DAP3: 155,687,833–155,740,132, forward strandDAP3GON4L: 155,749,659–155,859,439, reverse strandGON4LSYT11: 155,859,449–155,885,199, forward strandSYT11RIT1: 155,897,808–155,911,408, reverse strandRIT1KHDC4: 155,913,043–155,934,416, reverse strandKHDC4RXFP4: 155,941,638–155,943,087, forward strandRXFP4ARHGEF2: 155,944,685–156,007,070, reverse strandARHGEF2SSR2: 156,009,041–156,020,972, reverse strandSSR2UBQLN4: 156,026,961–156,053,814, reverse strandUBQLN4LAMTOR2: 156,053,916–156,058,817, forward strandLAMTOR2RAB25: 156,061,147–156,070,514, forward strandRAB25MEX3A: 156,072,013–156,082,465, reverse strandMEX3ALMNA: 156,082,572–156,140,085, forward strandLMNASEMA4A: 156,153,585–156,177,744, forward strandSEMA4ASLC25A44: 156,193,932–156,212,796, forward strandSLC25A44PMF1-BGLAP: 156,212,982–156,243,332, forward strandPMF1-BGLAPPMF1: 156,212,989–156,240,585, forward strandPMF1BGLAP: 156,242,154–156,243,317, forward strandBGLAPPAQR6: 156,243,318–156,248,647, reverse strandSMG5: 156,249,223–156,282,862, reverse strandTMEM79: 156,282,928–156,293,185, forward strandTMEM79GLMP: 156,290,088–156,295,699, reverse strandGLMPVHLL: 156,298,624–156,299,307, reverse strandVHLLCCT3: 156,308,792–156,367,873, reverse strandCCT3TSACC: 156,337,314–156,347,019, forward strandTSACCRHBG: 156,369,015–156,385,221, forward strandRHBGMEF2D: 156,463,727–156,501,266, reverse strandMEF2DIQGAP3: 156,525,405–156,572,604, reverse strandIQGAP3TTC24: 156,579,723–156,587,719, forward strandTTC24NAXE: 156,591,738–156,609,507, forward strandNAXEGPATCH4: 156,594,301–156,601,496, reverse strandGPATCH4HAPLN2: 156,619,331–156,626,590, forward strandHAPLN2BCAN: 156,641,390–156,659,532, forward strandBCANDiagram of SEMA4A: 15 exons on the forward strand of chromosome 1Exon 8: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 1: 156,153,585–156,153,764, 180 basesExon 2: 156,154,550–156,154,717, 168 basesExon 3: 156,156,414–156,156,574, 161 basesExon 4: 156,158,070–156,158,132, 63 basesExon 5: 156,158,388–156,158,486, 99 basesExon 6: 156,158,719–156,158,824, 106 basesExon 7: 156,160,443–156,160,559, 117 basesExon 8: 156,160,905–156,161,029, 125 basesExon 9: 156,161,346–156,161,518, 173 basesExon 10: 156,162,944–156,163,094, 151 basesExon 11: 156,172,826–156,173,006, 181 basesExon 12: 156,174,822–156,174,940, 119 basesExon 13: 156,175,086–156,175,243, 158 basesExon 14: 156,175,556–156,175,656, 101 basesExon 15: 156,176,405–156,177,744, 1,340 bases12468101214155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.2 kb of the gene's 24.2 kb; 2,286 of those bases code for the protein.

How a genome test reads SEMA4A

2

positions in SEMA4A where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 24.2 kb of SEMA4A, introns included, not only the 3.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SEMA4A gene: semaphorin 4A. Retrieved 17 October 2026, from https://dantelabs.com/genes/sema4a

Vancouver

Dante Labs. SEMA4A gene: semaphorin 4A [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/sema4a

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