Gene
ADGRG1
adhesion G protein-coupled receptor G1
- HGNC 4512↗(opens in a new tab)
- Ensembl gene ENSG00000205336↗(opens in a new tab)
- NCBI Gene 9289↗(opens in a new tab)
Summary
- Cytogenetic location
- 16q21
- Coordinates
- Chromosome 16: 57,628,630–57,665,567 (GRCh38)
- Exons
- 14 exons across 36.9 kb
- Protein
- 687 amino acids
- Also known as
- TM7LN4, TM7XN1
- Previous symbols
- GPR56
- MANE Select transcript
- ENST00000562631.7NM_201525.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads ADGRG1 yet. The test sequences your whole genome, so your data includes it all the same.
How ADGRG1 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.3 kb of the gene's 36.9 kb; 2,064 of those bases code for the protein.
How a genome test reads ADGRG1
64
positions in ADGRG1 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 36.9 kb of ADGRG1, introns included, not only the 4.3 kb of exons.
Traits linked to ADGRG1
The Human Phenotype Ontology lists these as features of the rare conditions ADGRG1 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Epilepsy
- Frontal polymicrogyria
- Global developmental delay
- Hypoplasia of the pons
- Instability or lack of coordination of central trunk muscles
- Intellectual disability
- Lack of coordination of movement
- Language impairment
Show 35 more traits
- Perisylvian polymicrogyria
- Ventriculomegaly
- Abnormality of neuronal migration
- Bilateral perisylvian polymicrogyria
- Cerebellar dysplasia
- Cerebral dysmyelination
- Cortical dysplasia
- Motor delay
- Abnormal pyramidal sign
- Abnormality of balance
- Abnormality of the cerebellum
- Bilateral tonic-clonic seizure with generalized onset
- Cerebellar vermis hypoplasia
- Delayed speech and language development
- EEG with central focal spikes
- EEG with parietal focal spikes
- EEG with polyspike wave complexes
- Increased reflexes
- Intellectual disability, severe
- Perisylvian predominant thick cortex pachygyria
- Seizure affecting one half of brain
- Specific learning disability
- Difficulty articulating speech
- EEG with frontal focal spikes
- Focal sensory seizure
- Generalized myoclonic seizure
- Infantile spasms
- Oromotor apraxia
- Partial paralysis of legs
- Small brainstem
- Sudden loss of muscle tone
- Typical absence seizure
- Babinski sign
- Small cerebellum
- Wide based walk
Abnormality of head or neck
- Weakness of facial musculature
- Abnormality of masticatory muscle
- Abnormally small head
- Blockage of the rear opening of the nasal cavity
- Drooling
- Facial diplegia
- Increased head circumference
- Little lower jaw
Show 1 more trait
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). ADGRG1 gene: adhesion G protein-coupled receptor G1. Retrieved 16 October 2026, from https://dantelabs.com/genes/adgrg1
Dante Labs. ADGRG1 gene: adhesion G protein-coupled receptor G1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/adgrg1
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