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Gene

DNAJC6

DnaJ heat shock protein family (Hsp40) member C6

Summary

Cytogenetic location
1p31.3
Coordinates
Chromosome 1: 65,309,543–65,415,871 (GRCh38)
Exons
19 exons across 106.3 kb
Protein
970 amino acids
Also known as
KIAA0473, PARK19
MANE Select transcript
ENST00000371069.5NM_001256864.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Parkinson Disease

    • A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      LRRK2 kinase inhibitor trials, substrate reduction therapy for GBA variants, α-synuclein-targeted approaches, dopaminergic medications, levodopa

How DNAJC6 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where DNAJC6 sits. DNAJC6 and 5 genes near it on chromosome 1, from 64,862,707 to 65,862,706.Chromosome 11p31.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4465 Mb65.2 Mb65.4 Mb65.6 Mb65.8 MbJAK1: 64,833,223–65,067,754, reverse strandJAK1AK4: 65,146,902–65,232,196, forward strandAK4DNAJC6: 65,309,543–65,415,871, forward strandDNAJC6LEPR: 65,420,543–65,641,559, forward strandLEPRLEPROT: 65,420,547–65,436,051, forward strandLEPROTPDE4B: 65,792,514–66,374,582, forward strandPDE4BDiagram of DNAJC6: 19 exons on the forward strand of chromosome 1Exon 1: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 17: 1 known disease-causing siteExon 1: 65,309,543–65,309,938, 396 basesExon 2: 65,364,635–65,364,785, 151 basesExon 3: 65,365,885–65,365,934, 50 basesExon 4: 65,366,048–65,366,196, 149 basesExon 5: 65,379,402–65,379,524, 123 basesExon 6: 65,384,193–65,384,326, 134 basesExon 7: 65,385,712–65,385,906, 195 basesExon 8: 65,386,812–65,386,929, 118 basesExon 9: 65,388,336–65,388,415, 80 basesExon 10: 65,389,256–65,389,449, 194 basesExon 11: 65,389,547–65,389,627, 81 basesExon 12: 65,392,431–65,392,865, 435 basesExon 13: 65,394,898–65,395,032, 135 basesExon 14: 65,398,813–65,398,881, 69 basesExon 15: 65,401,761–65,401,880, 120 basesExon 16: 65,405,870–65,406,133, 264 basesExon 17: 65,408,641–65,408,783, 143 basesExon 18: 65,411,250–65,411,426, 177 basesExon 19: 65,412,924–65,415,871, 2,948 bases151015195′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6 kb of the gene's 106.3 kb; 2,913 of those bases code for the protein.

How a genome test reads DNAJC6

8

positions in DNAJC6 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 106.3 kb of DNAJC6, introns included, not only the 6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DNAJC6 gene: DnaJ heat shock protein family (Hsp40) member C6. Retrieved 16 October 2026, from https://dantelabs.com/genes/dnajc6

Vancouver

Dante Labs. DNAJC6 gene: DnaJ heat shock protein family (Hsp40) member C6 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dnajc6

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