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Gene

SLC25A15

solute carrier family 25 member 15

Summary

Cytogenetic location
13q14.11
Coordinates
Chromosome 13: 40,789,611–40,812,460 (GRCh38)
Exons
7 exons across 22.9 kb
Protein
301 amino acids
Also known as
ORC1, lnc-HC, D13S327
Previous symbols
ORNT1, HHH
MANE Select transcript
ENST00000338625.9NM_014252.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Urea Cycle Disorder

    • A genetic inborn error of metabolism characterized by the deficiency of one of the enzymes necessary for the urea cycle. It results in accumulation of ammonia in the body.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Nitrogen scavenger therapy (sodium benzoate, glycerol phenylbutyrate/Ravicti); protein-restricted diet with essential amino acid supplementation; emergency hyperammonemia protocols; liver transplantation (curative); mRNA therapy trials for OTC; carglumic acid for NAGS deficiency

How SLC25A15 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 13, with a bracket where SLC25A15 sits. SLC25A15 and 7 genes near it on chromosome 13, from 40,301,036 to 41,301,035.Chromosome 1313q14.11p13p12p11.2p11.1q11q12.11q12.12q12.13q12.2q12.3q13.1q13.2q13.3q14.11q14.12q14.13q14.2q14.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q3440.4 Mb40.6 Mb40.8 Mb41 Mb41.2 MbFOXO1: 40,555,667–40,667,612, reverse strandFOXO1MRPS31: 40,727,694–40,771,351, reverse strandMRPS31SLC25A15: 40,789,611–40,812,460, forward strandSLC25A15ELF1: 40,931,241–41,061,692, reverse strandELF1WBP4: 41,060,607–41,084,012, forward strandWBP4KBTBD6: 41,127,569–41,132,802, reverse strandKBTBD6KBTBD7: 41,189,834–41,194,569, reverse strandKBTBD7MTRF1: 41,216,145–41,311,831, reverse strandMTRF1Diagram of SLC25A15: 7 exons on the forward strand of chromosome 13Exon 2: 4 known disease-causing sitesExon 3: 17 known disease-causing sitesExon 4: 14 known disease-causing sitesExon 5: 11 known disease-causing sitesExon 6: 8 known disease-causing sitesExon 7: 4 known disease-causing sitesExon 1: 40,789,611–40,789,663, 53 basesExon 2: 40,793,158–40,793,281, 124 basesExon 3: 40,799,057–40,799,315, 259 basesExon 4: 40,805,118–40,805,255, 138 basesExon 5: 40,807,294–40,807,463, 170 basesExon 6: 40,808,438–40,808,596, 159 basesExon 7: 40,809,543–40,812,460, 2,918 bases12345675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.8 kb of the gene's 22.9 kb; 906 of those bases code for the protein.

How a genome test reads SLC25A15

71

positions in SLC25A15 where ClinVar classes a change as pathogenic or likely pathogenic

21 of them (30%) fall in regions short reads find hard.

  • Low mappability (2 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (21 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 22.9 kb of SLC25A15, introns included, not only the 3.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SLC25A15 gene: solute carrier family 25 member 15. Retrieved 17 October 2026, from https://dantelabs.com/genes/slc25a15

Vancouver

Dante Labs. SLC25A15 gene: solute carrier family 25 member 15 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/slc25a15

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