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Gene

KIF1C

kinesin family member 1C

Summary

Cytogenetic location
17p13.2
Coordinates
Chromosome 17: 4,997,950–5,028,401 (GRCh38)
Exons
23 exons across 30.5 kb
Protein
1,103 amino acids
Also known as
SPAX2, SPG58
Previous symbols
SAX2
MANE Select transcript
ENST00000320785.10NM_006612.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Hereditary Spastic Paraplegia

      • Hereditary Spastic Paraplegia (All Types)

        One of 66 genes linked to it

        Umbrella term covering all hereditary spastic paraplegias, including SPG4 (SPAST), the most common dominant form, and SPG5A, SPG6, SPG10, SPG18, SPG30 and SPG31.

        • 2 GenCC submitters rate it definitive or strong

    How KIF1C is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 17, with a bracket where KIF1C sits. KIF1C and 42 genes near it on chromosome 17, from 4,513,176 to 5,513,175.Chromosome 1717p13.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.34.6 Mb4.8 Mb5 Mb5.2 Mb5.4 MbSPNS2: 4,498,839–4,539,036, forward strandSPNS2MYBBP1A: 4,538,897–4,555,403, reverse strandMYBBP1AGGT6: 4,556,342–4,560,818, reverse strandGGT6SMTNL2: 4,583,999–4,608,798, forward strandSMTNL2ALOX15: 4,629,736–4,642,294, reverse strandALOX15PELP1: 4,669,774–4,704,337, reverse strandPELP1ARRB2: 4,710,393–4,721,500, forward strandARRB2MED11: 4,731,411–4,733,610, forward strandMED11CXCL16: 4,732,915–4,740,064, reverse strandCXCL16ZMYND15: 4,739,108–4,746,119, forward strandTM4SF5: 4,771,835–4,783,220, forward strandVMO1: 4,785,281–4,790,406, reverse strandGLTPD2: 4,788,927–4,790,734, forward strandGLTPD2PSMB6: 4,796,144–4,798,503, forward strandPSMB6C17orf114: 4,801,159–4,807,013, reverse strandC17orf114PLD2: 4,807,074–4,823,434, forward strandPLD2MINK1: 4,833,147–4,898,065, forward strandMINK1CHRNE: 4,897,769–4,934,438, reverse strandCHRNEC17orf107: 4,899,418–4,902,934, forward strandGP1BA: 4,932,261–4,935,023, forward strandSLC25A11: 4,934,570–4,940,156, reverse strandRNF167: 4,939,997–4,945,223, forward strandPFN1: 4,945,652–4,950,517, reverse strandENO3: 4,948,034–4,957,132, forward strandENO3SPAG7: 4,959,226–4,967,835, reverse strandSPAG7CAMTA2: 4,967,992–4,987,684, reverse strandCAMTA2INCA1: 4,988,130–4,999,117, reverse strandINCA1KIF1C: 4,997,950–5,028,401, forward strandKIF1CSLC52A1: 5,032,600–5,052,009, reverse strandSLC52A1ZFP3: 5,078,241–5,096,376, forward strandZFP3ZNF232: 5,105,269–5,123,162, reverse strandZNF232USP6: 5,116,032–5,175,034, forward strandUSP6ZNF594: 5,174,019–5,191,907, reverse strandZNF594SCIMP: 5,208,915–5,234,869, reverse strandSCIMPRABEP1: 5,282,258–5,386,871, forward strandRABEP1NUP88: 5,359,641–5,420,164, reverse strandNUP88RPAIN: 5,419,066–5,432,888, forward strandRPAINC1QBP: 5,432,625–5,448,830, reverse strandC1QBPDHX33: 5,440,917–5,469,031, reverse strandDHX33DERL2: 5,471,254–5,486,817, reverse strandDERL2MIS12: 5,486,285–5,492,080, forward strandMIS12NLRP1: 5,499,415–5,619,424, reverse strandSMIM48: 5,499,427–5,501,013, reverse strandSMIM48Diagram of KIF1C: 23 exons on the forward strand of chromosome 17Exon 3: 2 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 5: 2 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 9: 3 known disease-causing sitesExon 12: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 21: 1 known disease-causing siteExon 22: 2 known disease-causing sitesExon 23: 2 known disease-causing sitesExon 1: 4,997,950–4,998,156, 207 basesExon 2: 4,999,850–4,999,970, 121 basesExon 3: 5,000,220–5,000,352, 133 basesExon 4: 5,000,772–5,000,848, 77 basesExon 5: 5,001,222–5,001,401, 180 basesExon 6: 5,002,059–5,002,124, 66 basesExon 7: 5,002,464–5,002,642, 179 basesExon 8: 5,002,731–5,002,842, 112 basesExon 9: 5,003,612–5,003,689, 78 basesExon 10: 5,003,851–5,003,916, 66 basesExon 11: 5,003,998–5,004,073, 76 basesExon 12: 5,004,567–5,004,645, 79 basesExon 13: 5,004,855–5,005,000, 146 basesExon 14: 5,006,915–5,007,084, 170 basesExon 15: 5,007,263–5,007,342, 80 basesExon 16: 5,007,467–5,007,542, 76 basesExon 17: 5,013,653–5,013,732, 80 basesExon 18: 5,014,743–5,014,837, 95 basesExon 19: 5,019,996–5,020,079, 84 basesExon 20: 5,020,492–5,020,678, 187 basesExon 21: 5,020,806–5,020,878, 73 basesExon 22: 5,022,092–5,022,709, 618 basesExon 23: 5,023,468–5,028,401, 4,934 bases15101520235′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 7.9 kb of the gene's 30.5 kb; 3,312 of those bases code for the protein.

    How a genome test reads KIF1C

    26

    positions in KIF1C where ClinVar classes a change as pathogenic or likely pathogenic

    4 of them (15%) fall in regions short reads find hard.

    • Segmental duplications (4 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

    A whole genome covers all 30.5 kb of KIF1C, introns included, not only the 7.9 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). KIF1C gene: kinesin family member 1C. Retrieved 17 October 2026, from https://dantelabs.com/genes/kif1c

    Vancouver

    Dante Labs. KIF1C gene: kinesin family member 1C [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kif1c

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