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Gene

FBXO7

F-box protein 7

Summary

Cytogenetic location
22q12.3
Coordinates
Chromosome 22: 32,474,811–32,498,829 (GRCh38)
Exons
9 exons across 24 kb
Protein
522 amino acids
Also known as
FBX7, Fbx, PARK15
MANE Select transcript
ENST00000266087.12NM_012179.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Parkinson Disease

    • A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      LRRK2 kinase inhibitor trials, substrate reduction therapy for GBA variants, α-synuclein-targeted approaches, dopaminergic medications, levodopa

How FBXO7 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 22, with a bracket where FBXO7 sits. FBXO7 and 9 genes near it on chromosome 22, from 31,986,820 to 32,986,819.Chromosome 2222q12.3p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3332 Mb32.2 Mb32.4 Mb32.6 Mb32.8 MbSLC5A1: 32,043,050–32,113,029, forward strandSLC5A1C22orf42: 32,149,006–32,159,322, reverse strandC22orf42RFPL2: 32,190,433–32,205,073, reverse strandRFPL2SLC5A4: 32,216,637–32,255,347, reverse strandSLC5A4RFPL3: 32,354,885–32,361,161, forward strandRFPL3RTCB: 32,387,575–32,412,265, reverse strandRTCBBPIFC: 32,413,845–32,464,484, reverse strandBPIFCFBXO7: 32,474,811–32,498,829, forward strandFBXO7SYN3: 32,507,820–33,058,388, reverse strandSYN3TIMP3: 32,801,576–32,863,042, forward strandTIMP3Diagram of FBXO7: 9 exons on the forward strand of chromosome 22Exon 1: 3 known disease-causing sitesExon 2: 8 known disease-causing sitesExon 3: 5 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 5: 1 known disease-causing siteExon 6: 5 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 9: 10 known disease-causing sitesExon 1: 32,474,811–32,475,124, 314 basesExon 2: 32,478,981–32,479,275, 295 basesExon 3: 32,483,897–32,484,124, 228 basesExon 4: 32,485,068–32,485,209, 142 basesExon 5: 32,487,745–32,487,828, 84 basesExon 6: 32,491,086–32,491,181, 96 basesExon 7: 32,493,105–32,493,281, 177 basesExon 8: 32,495,493–32,495,530, 38 basesExon 9: 32,498,144–32,498,829, 686 bases1234567895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 24 kb; 1,569 of those bases code for the protein.

How a genome test reads FBXO7

42

positions in FBXO7 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 24 kb of FBXO7, introns included, not only the 2.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FBXO7 gene: F-box protein 7. Retrieved 16 October 2026, from https://dantelabs.com/genes/fbxo7

Vancouver

Dante Labs. FBXO7 gene: F-box protein 7 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/fbxo7

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