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Trait

Long-tract sign

Long-tract signs refer to symptoms that are attributable to the involvement of the long fiber tracts in the spinal cord, which connect the spinal cord to the brain and mediate spinal and motor functions. These include spasticity, hyperreflexia, and abnormal reflexes such as Babinski or Hoffman's sign. If possible, it is preferable to use the precise HPO terms for these abnormalities.

HPO HP:0002423

Summary

Also called
Long tract signs, Long-tract signs
Body system
Abnormality of the nervous system

7 genes linked to Long-tract sign

Changes in these genes cause rare conditions in which Long-tract sign is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
CYP27A1cytochrome P450 family 27 subfamily A member 1Sometimes (5–29%)In 1 condition
APOEapolipoprotein ENot recordedIn 1 condition
APPamyloid beta precursor proteinNot recordedIn 1 condition
GTF2E2general transcription factor IIE subunit 2Not recordedIn 1 condition
MPOmyeloperoxidaseNot recordedIn 1 condition
PLAUplasminogen activator, urokinaseNot recordedIn 1 condition
TNFRSF11ATNF receptor superfamily member 11aNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal spinal cord physiology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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