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Gene

VPS13C

vacuolar protein sorting 13 homolog C

Summary

Cytogenetic location
15q22.2
Coordinates
Chromosome 15: 61,852,389–62,060,447 (GRCh38)
Exons
85 exons across 208.1 kb
Protein
3,753 amino acids
Also known as
FLJ20136, FLJ10381, KIAA1421, BLTP5C, PARK23
MANE Select transcript
ENST00000644861.2NM_020821.3
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Parkinson Disease

    • A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      LRRK2 kinase inhibitor trials, substrate reduction therapy for GBA variants, α-synuclein-targeted approaches, dopaminergic medications, levodopa

How VPS13C is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where VPS13C sits. VPS13C and 3 genes near it on chromosome 15, from 61,456,418 to 62,456,417.Chromosome 1515q22.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.361.6 Mb61.8 Mb62 Mb62.2 Mb62.4 MbVPS13C: 61,852,389–62,060,447, reverse strandVPS13CC2CD4A: 62,066,977–62,070,917, forward strandC2CD4AC2CD4B: 62,158,336–62,165,719, reverse strandC2CD4BTLN2: 62,390,489–62,844,631, forward strandTLN2Diagram of VPS13C: 85 exons on the reverse strand of chromosome 15Exon 83: 1 known disease-causing siteExon 81: 1 known disease-causing siteExon 78: 1 known disease-causing siteExon 74: 1 known disease-causing siteExon 71: 1 known disease-causing siteExon 69: 3 known disease-causing sitesExon 68: 1 known disease-causing siteExon 67: 1 known disease-causing siteExon 66: 1 known disease-causing siteExon 65: 1 known disease-causing siteExon 64: 1 known disease-causing siteExon 60: 1 known disease-causing siteExon 54: 1 known disease-causing siteExon 51: 1 known disease-causing siteExon 49: 1 known disease-causing siteExon 48: 2 known disease-causing sitesExon 47: 1 known disease-causing siteExon 43: 1 known disease-causing siteExon 37: 1 known disease-causing siteExon 35: 1 known disease-causing siteExon 32: 1 known disease-causing siteExon 23: 1 known disease-causing siteExon 15: 2 known disease-causing sitesExon 14: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 85: 61,852,389–61,854,558, 2,170 basesExon 84: 61,854,871–61,854,954, 84 basesExon 83: 61,856,286–61,856,409, 124 basesExon 82: 61,863,440–61,863,528, 89 basesExon 81: 61,868,659–61,868,773, 115 basesExon 80: 61,869,500–61,869,623, 124 basesExon 79: 61,871,989–61,872,034, 46 basesExon 78: 61,873,246–61,873,409, 164 basesExon 77: 61,874,876–61,874,951, 76 basesExon 76: 61,875,732–61,875,845, 114 basesExon 75: 61,876,973–61,877,054, 82 basesExon 74: 61,878,607–61,878,746, 140 basesExon 73: 61,880,609–61,880,722, 114 basesExon 72: 61,880,843–61,880,954, 112 basesExon 71: 61,881,563–61,881,632, 70 basesExon 70: 61,881,747–61,881,828, 82 basesExon 69: 61,882,596–61,882,736, 141 basesExon 68: 61,884,128–61,884,269, 142 basesExon 67: 61,890,165–61,890,400, 236 basesExon 66: 61,907,264–61,907,390, 127 basesExon 65: 61,908,992–61,909,125, 134 basesExon 64: 61,910,177–61,910,305, 129 basesExon 63: 61,911,840–61,912,004, 165 basesExon 62: 61,913,311–61,913,415, 105 basesExon 61: 61,915,633–61,916,022, 390 basesExon 60: 61,917,341–61,917,635, 295 basesExon 59: 61,918,136–61,918,257, 122 basesExon 58: 61,919,289–61,919,449, 161 basesExon 57: 61,920,067–61,920,331, 265 basesExon 56: 61,920,498–61,920,647, 150 basesExon 55: 61,921,947–61,922,033, 87 basesExon 54: 61,922,397–61,922,762, 366 basesExon 53: 61,925,456–61,925,548, 93 basesExon 52: 61,927,091–61,927,320, 230 basesExon 51: 61,929,501–61,929,748, 248 basesExon 50: 61,931,090–61,931,259, 170 basesExon 49: 61,934,219–61,934,331, 113 basesExon 48: 61,936,597–61,936,750, 154 basesExon 47: 61,940,647–61,940,794, 148 basesExon 46: 61,941,763–61,942,067, 305 basesExon 45: 61,945,715–61,945,882, 168 basesExon 44: 61,946,307–61,946,410, 104 basesExon 43: 61,947,193–61,947,309, 117 basesExon 42: 61,949,443–61,949,605, 163 basesExon 41: 61,950,358–61,950,417, 60 basesExon 40: 61,950,945–61,951,024, 80 basesExon 39: 61,951,824–61,951,980, 157 basesExon 38: 61,954,421–61,954,554, 134 basesExon 37: 61,958,608–61,958,716, 109 basesExon 36: 61,959,448–61,959,595, 148 basesExon 35: 61,961,589–61,961,893, 305 basesExon 34: 61,962,371–61,962,538, 168 basesExon 33: 61,962,749–61,962,852, 104 basesExon 32: 61,963,835–61,963,951, 117 basesExon 31: 61,964,699–61,964,861, 163 basesExon 30: 61,966,083–61,966,142, 60 basesExon 29: 61,967,368–61,967,447, 80 basesExon 28: 61,969,299–61,969,452, 154 basesExon 27: 61,972,625–61,972,764, 140 basesExon 26: 61,973,454–61,973,532, 79 basesExon 25: 61,974,288–61,974,417, 130 basesExon 24: 61,977,082–61,977,199, 118 basesExon 23: 61,978,626–61,978,749, 124 basesExon 22: 61,981,342–61,981,478, 137 basesExon 21: 61,982,459–61,982,573, 115 basesExon 20: 61,983,820–61,984,012, 193 basesExon 19: 61,984,857–61,984,999, 143 basesExon 18: 61,991,000–61,991,094, 95 basesExon 17: 61,991,673–61,991,802, 130 basesExon 16: 62,000,564–62,000,626, 63 basesExon 15: 62,007,308–62,007,479, 172 basesExon 14: 62,008,655–62,008,761, 107 basesExon 13: 62,010,472–62,010,599, 128 basesExon 12: 62,012,107–62,012,164, 58 basesExon 11: 62,013,039–62,013,119, 81 basesExon 10: 62,013,933–62,013,992, 60 basesExon 9: 62,020,479–62,020,538, 60 basesExon 8: 62,023,411–62,023,520, 110 basesExon 7: 62,023,780–62,023,845, 66 basesExon 6: 62,028,358–62,028,420, 63 basesExon 5: 62,033,441–62,033,542, 102 basesExon 4: 62,034,957–62,035,052, 96 basesExon 3: 62,041,324–62,041,366, 43 basesExon 2: 62,044,212–62,044,255, 44 basesExon 1: 62,060,275–62,060,447, 173 bases85807060504030201015′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 13.4 kb of the gene's 208.1 kb; 11,262 of those bases code for the protein.

How a genome test reads VPS13C

37

positions in VPS13C where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 208.1 kb of VPS13C, introns included, not only the 13.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). VPS13C gene: vacuolar protein sorting 13 homolog C. Retrieved 17 October 2026, from https://dantelabs.com/genes/vps13c

Vancouver

Dante Labs. VPS13C gene: vacuolar protein sorting 13 homolog C [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/vps13c

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