Gene
MT-TL2
mitochondrially encoded tRNA-Leu (CUN) 2
- HGNC 7491(opens in a new tab)
- Ensembl gene ENSG00000210191(opens in a new tab)
- NCBI Gene 4568(opens in a new tab)
Summary
- Cytogenetic location
- mitochondria
- Also known as
- TRNL2
- Previous symbols
- MTTL2
- Locus type
- RNA, transfer
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads MT-TL2 yet. The test sequences your whole genome, so your data includes it all the same.
How a genome test reads MT-TL2
3
positions in MT-TL2 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
Traits linked to MT-TL2
The Human Phenotype Ontology lists these as features of the rare conditions MT-TL2 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Episodic hemiplegia
- Abnormal autonomic nervous system physiology
- Ataxia
- Behavioral abnormality
- Brisk reflexes
- Delayed speech and language development
- Dystonia
- Epilepsy
Show 28 more traits
- Intellectual disability
- Neurodevelopmental delay
- Tetraparesis
- Abnormal pyramidal sign
- Absent reflexes
- Aggressive behavior
- Bulbar signs
- Can't control feelings
- Chorea
- Choreoathetosis
- Depression
- Difficulty articulating speech
- Focal motor seizure
- Grand mal seizures
- Headache
- Impulsivity
- Increased reflexes
- Intellectual disability, mild
- Paroxysmal dyskinesia
- Repeated seizures without recovery between them
- Tremor
- Worsening neurological symptoms
- Brain imaging abnormality
- Dementia
- EEG abnormality
- Encephalopathy
- Migraine
- Weakness of one side of body
Abnormality of the cardiovascular system
- Abnormal T-wave
- Cardiac conduction abnormality
- Abnormal heart rate
- Disease of the heart muscle
- Abnormal left ventricular function
- Cardiac failure
- High blood pressure
- Left ventricular hypertrophy
Show 2 more traits
Abnormality of the digestive system
- Abnormality of the gastrointestinal tract
- Gastrointestinal dysmotility
- Abdominal bloating
- Anorexia
- Constipation
- Diarrhea
- Oral-pharyngeal dysphagia
- Poor swallowing
Show 2 more traits
Abnormality of the musculoskeletal system
- Muscle abnormality related to mitochondrial dysfunction
- Axial muscle weakness
- Decreased lung function due to weak breathing muscles
- EMG abnormality
- Progressive proximal muscle weakness
- Ragged-red muscle fibers
- Low muscle tone
- Rigidity
Show 2 more traits
External links
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). MT-TL2 gene: mitochondrially encoded tRNA-Leu (CUN) 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/mt-tl2
Dante Labs. MT-TL2 gene: mitochondrially encoded tRNA-Leu (CUN) 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/mt-tl2
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