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Gene

ACADS

acyl-CoA dehydrogenase short chain

Summary

Cytogenetic location
12q24.31
Coordinates
Chromosome 12: 120,725,826–120,740,008 (GRCh38)
Exons
10 exons across 14.2 kb
Protein
412 amino acids
Inheritance
Autosomal recessive
Also known as
SCAD, ACAD3
MANE Select transcript
ENST00000242592.9NM_000017.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Fatty Acid Oxidation & Carnitine Cycle Disorders

    • Disorders of Fatty Acid Oxidation and KetogenesisAutosomal recessive

      A group of enzyme and transporter defects, including MCAD, VLCAD, LCHAD, SCAD and HADH deficiency, primary carnitine deficiency and carnitine-acylcarnitine translocase deficiency, that can cause low blood sugar, muscle breakdown, heart and liver problems during periods of fasting or illness.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing allows avoidance of prolonged fasting, an emergency plan for illness and, where relevant, carnitine or dietary fat modification, which can prevent life-threatening episodes.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How ACADS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where ACADS sits. ACADS and 24 genes near it on chromosome 12, from 120,232,917 to 121,232,916.Chromosome 1212q24.31p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.33120.4 Mb120.6 Mb120.8 Mb121 Mb121.2 MbPXN: 120,210,439–120,265,800, reverse strandPXNSIRT4: 120,292,162–120,313,249, forward strandSIRT4PLA2G1B: 120,322,115–120,327,785, reverse strandPLA2G1BMSI1: 120,341,329–120,370,228, reverse strandMSI1COX6A1: 120,438,090–120,440,742, forward strand: 120,438,198–120,460,006, forward strandTRIAP1: 120,443,065–120,446,415, reverse strandGATC: 120,446,444–120,463,749, forward strandGATCSRSF9: 120,456,138–120,495,946, reverse strandSRSF9DYNLL1: 120,468,451–120,498,913, forward strandDYNLL1COQ5: 120,502,670–120,534,434, reverse strandCOQ5RNF10: 120,533,480–120,577,592, forward strandRNF10: 120,534,697–120,534,957, forward strandPOP5: 120,573,578–120,581,411, reverse strandPOP5CABP1: 120,640,563–120,667,327, forward strandCABP1MLEC: 120,686,800–120,704,285, forward strandMLECUNC119B: 120,710,426–120,723,640, forward strandUNC119BACADS: 120,725,826–120,740,008, forward strandACADSSPPL3: 120,762,510–120,904,414, reverse strandSPPL3HNF1A: 120,978,543–121,002,512, forward strandHNF1AC12orf43: 121,000,486–121,016,504, reverse strandC12orf43OASL: 121,017,763–121,039,246, reverse strandOASLP2RX7: 121,132,785–121,188,032, forward strandP2RX7P2RX4: 121,209,961–121,234,112, forward strandP2RX4CAMKK2: 121,217,103–121,298,308, reverse strandCAMKK2Diagram of ACADS: 10 exons on the forward strand of chromosome 12Exon 1: 4 known disease-causing sitesExon 2: 8 known disease-causing sitesExon 3: 7 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 5: 7 known disease-causing sitesExon 6: 6 known disease-causing sitesExon 7: 7 known disease-causing sitesExon 8: 7 known disease-causing sitesExon 9: 3 known disease-causing sitesExon 10: 10 known disease-causing sitesExon 1: 120,725,826–120,725,931, 106 basesExon 2: 120,727,026–120,727,189, 164 basesExon 3: 120,736,986–120,737,135, 150 basesExon 4: 120,737,356–120,737,467, 112 basesExon 5: 120,737,837–120,737,988, 152 basesExon 6: 120,738,280–120,738,450, 171 basesExon 7: 120,738,533–120,738,670, 138 basesExon 8: 120,738,820–120,738,915, 96 basesExon 9: 120,739,140–120,739,196, 57 basesExon 10: 120,739,296–120,740,008, 713 bases123456789105′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 14.2 kb; 1,239 of those bases code for the protein.

How a genome test reads ACADS

72

positions in ACADS where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 14.2 kb of ACADS, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ACADS gene: acyl-CoA dehydrogenase short chain. Retrieved 16 October 2026, from https://dantelabs.com/genes/acads

Vancouver

Dante Labs. ACADS gene: acyl-CoA dehydrogenase short chain [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/acads

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