Gene
NPAT
nuclear protein, coactivator of histone transcription
- HGNC 7896↗(opens in a new tab)
- Ensembl gene ENSG00000149308↗(opens in a new tab)
- NCBI Gene 4863↗(opens in a new tab)
Summary
- Cytogenetic location
- 11q22.3
- Coordinates
- Chromosome 11: 108,157,215–108,222,638 (GRCh38)
- Exons
- 18 exons across 65.4 kb
- Protein
- 1,427 amino acids
- Also known as
- E14, p220
- MANE Select transcript
- ENST00000278612.9NM_002519.3
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How NPAT is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 6.1 kb of the gene's 65.4 kb; 4,284 of those bases code for the protein.
Traits linked to NPAT
The Human Phenotype Ontology lists these as features of the rare conditions NPAT can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Glioblastoma multiforme
- Anxiety
- Attention deficit
- Behavioral abnormality
- Depression
- Epilepsy
- Irritability
- Migraine
Show 15 more traits
- Rise in pressure inside skull
- Abnormal gait
- Abnormal pyramidal sign
- Abnormal speech pattern
- Benign neoplasm of the central nervous system
- Cancer of early nerve cells
- Difficulty articulating speech
- Disorder of involuntary muscle movements
- Disturbed sensory perception
- Dysgraphia
- Hallucinations
- Loss of developmental milestones
- Memory impairment
- Paralysis or weakness of one side of body
- Pins and needles feeling
Abnormality of the digestive system
- Abdominal pain
- Constipation
- Malabsorption
- Nausea and vomiting
- Rectal tumor
- Cancer of the pancreas
- Colon tumor
- Hepatocellular carcinoma
Show 2 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). NPAT gene: nuclear protein, coactivator of histone transcription. Retrieved 17 October 2026, from https://dantelabs.com/genes/npat
Dante Labs. NPAT gene: nuclear protein, coactivator of histone transcription [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/npat
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